سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Khosravi, Mahjabin, Karami, Manizheh, Jalali Nadoushan, Mohammadreza, Hajnorouzi, Abazar. (1398). Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum. , 6(4), 321-328. doi: 10.22038/nmj.2019.06.0000010
Mahjabin Khosravi; Manizheh Karami; Mohammadreza Jalali Nadoushan; Abazar Hajnorouzi. "Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum". , 6, 4, 1398, 321-328. doi: 10.22038/nmj.2019.06.0000010
Khosravi, Mahjabin, Karami, Manizheh, Jalali Nadoushan, Mohammadreza, Hajnorouzi, Abazar. (1398). 'Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum', , 6(4), pp. 321-328. doi: 10.22038/nmj.2019.06.0000010
Khosravi, Mahjabin, Karami, Manizheh, Jalali Nadoushan, Mohammadreza, Hajnorouzi, Abazar. Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum. , 1398; 6(4): 321-328. doi: 10.22038/nmj.2019.06.0000010

Myelin enhancement of Multiple sclerosis model with gold nanoparticles into the corpus callosum

Nanomedicine Journal
مقاله 10، دوره 6، شماره 4، دی 2019، صفحه 321-328    اصل مقاله (2.44 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2019.06.0000010
نویسندگان
Mahjabin Khosravi1؛ Manizheh Karami* 1؛ Mohammadreza Jalali Nadoushan2؛ Abazar Hajnorouzi3
1Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
2Department of Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
3Department of Physics, Faculty of Basic Sciences, Shahed University, Tehran, Iran
چکیده
Objective(s): With no substantial cost, we injected L-arginine into the rat’s corpus callosum (CC) to create animal model of multiple sclerosis (MS) and investigated the pre-injection effect of gold nanoparticles (GNPs).
Materials and Methods: Adult male Wistar rat (250-300 g) was surgically cannulated at the CC, and after recovery it was injected L-arginine (3-200 µg/rat, intra-CC) once daily for 3 to 5 consecutive days. GNPs (0.001-0.01 µg/rat, intra-CC) were injected alone or prior to the L-arginine using the same procedure. Control group solely received saline (1 µL/rat, intra-CC). Brain was studied with luxol fast blue. Weight change was also analyzed via the analysis of variance (ANOVA).
Results: L-arginine significantly induced (p< 0.05) a reduction in the fiber density while the neurons increased (p< 0.05). Single GNPs reduced (p< 0.05) the fiber and neuron densities; however, pre-injection of NPs caused myelinated fibers and uniform density of neurons.
Conclusion: The L-arginine may trigger demyelination by pro-inflammatory nitric oxide (NO), and the GNPs may improve this effect.
کلیدواژه‌ها
Corpus callosum؛ Demyelination؛ Gold nanoparticle؛ L-Arginine؛ Multiple sclerosis؛ Nitric oxide؛ Rat
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