Gilany, Kambiz, Mohamadkhani, Ashraf, Chashmniam, Saeed, Shahnazari, Parisa, Amini, Mehdi, Arjmand, Babak, Malekzadeh, Reza, Nobakht Motlagh Ghoochani, Bibi Fatemeh. (1398). Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study. , 22(9), 1044-1049. doi: 10.22038/ijbms.2019.36669.8733
Kambiz Gilany; Ashraf Mohamadkhani; Saeed Chashmniam; Parisa Shahnazari; Mehdi Amini; Babak Arjmand; Reza Malekzadeh; Bibi Fatemeh Nobakht Motlagh Ghoochani. "Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study". , 22, 9, 1398, 1044-1049. doi: 10.22038/ijbms.2019.36669.8733
Gilany, Kambiz, Mohamadkhani, Ashraf, Chashmniam, Saeed, Shahnazari, Parisa, Amini, Mehdi, Arjmand, Babak, Malekzadeh, Reza, Nobakht Motlagh Ghoochani, Bibi Fatemeh. (1398). 'Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study', , 22(9), pp. 1044-1049. doi: 10.22038/ijbms.2019.36669.8733
Gilany, Kambiz, Mohamadkhani, Ashraf, Chashmniam, Saeed, Shahnazari, Parisa, Amini, Mehdi, Arjmand, Babak, Malekzadeh, Reza, Nobakht Motlagh Ghoochani, Bibi Fatemeh. Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study. , 1398; 22(9): 1044-1049. doi: 10.22038/ijbms.2019.36669.8733

Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study

Iranian Journal of Basic Medical Sciences
مقاله 10، دوره 22، شماره 9، آذر 2019، صفحه 1044-1049    اصل مقاله (652 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.36669.8733
نویسندگان
Kambiz Gilany1، 2؛ Ashraf Mohamadkhani3؛ Saeed Chashmniam4؛ Parisa Shahnazari1؛ Mehdi Amini1؛ Babak Arjmand5؛ Reza Malekzadeh3؛ Bibi Fatemeh Nobakht Motlagh Ghoochani* 6، 7
1Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
2Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
3Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4Department of Chemistry, Sharif University of Technology, Tehran, Iran
5Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
7Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
چکیده
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease.
Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups.
Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways.
Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms.
کلیدواژه‌ها
Diagnostic biomarkers؛ Hepatitis B virus؛ Metabolomics؛ NMR؛ Saliva
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