سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Beheshti, Farimah, Hosseini, Mahmoud, Hashemzehi, Milad, Soukhtanloo, Mohammad, Khazaei, Majid, Shafei, Mohammad Naser. (1398). The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats. , 22(8), 940-948. doi: 10.22038/ijbms.2019.36165.8616
Farimah Beheshti; Mahmoud Hosseini; Milad Hashemzehi; Mohammad Soukhtanloo; Majid Khazaei; Mohammad Naser Shafei. "The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats". , 22, 8, 1398, 940-948. doi: 10.22038/ijbms.2019.36165.8616
Beheshti, Farimah, Hosseini, Mahmoud, Hashemzehi, Milad, Soukhtanloo, Mohammad, Khazaei, Majid, Shafei, Mohammad Naser. (1398). 'The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats', , 22(8), pp. 940-948. doi: 10.22038/ijbms.2019.36165.8616
Beheshti, Farimah, Hosseini, Mahmoud, Hashemzehi, Milad, Soukhtanloo, Mohammad, Khazaei, Majid, Shafei, Mohammad Naser. The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats. , 1398; 22(8): 940-948. doi: 10.22038/ijbms.2019.36165.8616

The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 22، شماره 8، آبان 2019، صفحه 940-948    اصل مقاله (1.46 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.36165.8616
نویسندگان
Farimah Beheshti1، 2؛ Mahmoud Hosseini* 1؛ Milad Hashemzehi3؛ Mohammad Soukhtanloo4؛ Majid Khazaei5؛ Mohammad Naser Shafei6
1Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
3Iranshahr University of Medical Sciences, Iranshahr, Iran
4Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): The aim of current study was to evaluate improving effects of pioglitazone as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived neurotrophic factor (BDNF) and cytokines as well as tissue oxidative damage criteria in the hippocampus in a rat model of lipopolysaccharide (LPS) induced memory impairment.
Materials and Methods: The rats were classified and treated as follows (10 rats per group): (1) vehicle, (2) vehicle before LPS (1 mg/kg, 120 min before memory tests), (3-5) pioglitazone 10, 20 or 30 mg/kg 30 min before LPS. Finally, the hippocampal tissues were collected for biomedical analyses.
Results: In the Morris water maze test, the LPS group, had a longer latency to find the platform while they spent a shorter time in the target quadrant in the probe trial. In the passive avoidance test, the animals of the LPS group had shorter delay times to enter the dark compartment than those of the control group. Treatment with 20 and 30 mg of pioglitazone corrected these parameters. In the hippocampus of LPS group interleukin-6, tumor necrosis factor-α, nitric oxide metabolites, and malondialdehyde were higher while  thiol, BDNF, and IL-10 concentrations and the activities of catalase (CAT) and superoxide dismutase (SOD) were lower than the control group. Treatment by both doses of 20 and 30 mg of pioglitazone corrected the biochemical parameters in the hippocampus.
Conclusion: The current findings revealed that pioglitazone protected the rats from learning and memory impairment induced by LPS. The effects were associated with improvement of cytokines, oxidative stress criteria, and BDNF.
کلیدواژه‌ها
Brain-derived neurotrophic- factor؛ Cytokines learning؛ Lipopolysaccharide؛ Memory؛ Pioglitazone
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