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Karimi, Azam, Khajehpour, Lotfollah, Kesmati, Mahnaz. (1398). Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats. , 6(4), 301-310. doi: 10.22038/nmj.2019.06.000008
Azam Karimi; Lotfollah Khajehpour; Mahnaz Kesmati. "Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats". , 6, 4, 1398, 301-310. doi: 10.22038/nmj.2019.06.000008
Karimi, Azam, Khajehpour, Lotfollah, Kesmati, Mahnaz. (1398). 'Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats', , 6(4), pp. 301-310. doi: 10.22038/nmj.2019.06.000008
Karimi, Azam, Khajehpour, Lotfollah, Kesmati, Mahnaz. Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats. , 1398; 6(4): 301-310. doi: 10.22038/nmj.2019.06.000008

Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats

Nanomedicine Journal
مقاله 8، دوره 6، شماره 4، دی 2019، صفحه 301-310    اصل مقاله (507.55 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2019.06.000008
نویسندگان
Azam Karimi؛ Lotfollah Khajehpour* ؛ Mahnaz Kesmati
Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
چکیده
Objective(s): Nanoparticles of iron oxide (nFe2O3) are widely used in medicine and industry and could interfere with the brain processes associated with memory. The involvement of muscarinic cholinergic receptors in the process of memory formation has been confirmed. The present study aimed to investigate the possible interference of the cholinergic muscarinic receptors of the dorsal hippocampal CA1 area in the memory impairment induced by nFe2O3 in adult male rats.
Materials and Methods: In this study, we examined the possible involvement of the cholinergic muscarinic receptors of the dorsal hippocampal CA1 area in the memory impairment induced by nFe2O3. In total, 70 male rats were divided into 10 groups of saline (1 µl/rat)+saline (1 ml/kg; intraperitoneal [IP]), saline (1 µl/rat)+nFe2O3 (5 and 7.5 mg/kg; IP), pilocarpine (1 and 2 µg/rat)+saline (1 ml/kg), pilocarpine (1 and 2 µg/rat)+nFe2O3 (7.5 mg/kg; IP), scopolamine (1 and 2 µg/rat)+saline (1 ml/kg), and scopolamine (1 µg/rat)+ nFe2O3 (5 mg/kg; IP).
Results: Pilocarpine and scopolamine were injected intra-CA1 after training and before the IP administration of nFe2O3. The latency to enter the dark compartment in the step-through apparatus and locomotor activity was performed on the animals in an open field at 24 hours and seven days after training. The results indicated that nFe2O3 (7.5 mg/kg) decreased memory retrieval (P
کلیدواژه‌ها
Cholinergic system؛ Hippocampus؛ Iron oxide؛ Memory؛ Nanoparticle
مراجع

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