Antimalarial activity of extract and fractions of Castanopsis costata (Blume) A.DC | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 8، دوره 9، شماره 5، آذر و دی 2019، صفحه 474-481 اصل مقاله (452.2 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2019.13188 | ||
| نویسندگان | ||
| Maulana Alkandahri1؛ Afiat Berbudi* 2؛ Novi Vicahyani Utami Utami3؛ Anas Subarnas4 | ||
| 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University | ||
| 2Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia. | ||
| 3Department of Biomedical Sciences, Pharmacology Division, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia. | ||
| 4Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jatinangor, West Java, Indonesia. | ||
| چکیده | ||
| Objective: One of the biggest health problems in the world, which occurs in more than 90 countries, is the spread of malaria. Cep-cepan leaves (Castanopsis costata), was empirically used as an antimalarial herb in North Sumatra. Since its use has not been scientifically studied, we investigated the antimalarial activity of extract and fractions of C. costata against Plasmodium berghei ANKA (PbA) in a mouse model. Materials and Methods: This experimental study was conducted using 32 male Balb/C mice. PbA inoculation was performed intraperitoneally with 106 parasites/mouse. Immediately after parasitemia reach >2% (day 0), the mice were treated orally with daily artesunate (36.4 mg/kg/day) (positive control), ethanolic extract (100, 200, and 400 mg/kg/day), and the fractions of water, ethyl acetate and n-hexane (108 mg/kg/day each) for 5 consecutive days (from day 0 to 4). Parasitemia inhibition was observed to determine the antimalarial activity of each type of C. costata extract and fractions. Results: The administration of C. costata leaves ethanolic extract (100, 200, and 400 mg/kg) significantly inhibited the growth of PbA in Balb/C mice (42.66%, 66.2 1% and 80.99 % inhibition, respectively) (p<0.05). Similarly, all C. costata fractions also produced antimalarial activity against PbA with administration of the ethyl acetate fraction presenting the highest activity (79.85 % inhibition). Conclusion: The C. costata leaves showed antimalarial activity against PbA. However, further studies are necessary to elucidate the underlying mechanisms of this effect and the active compounds involved. Our current study revealed that C.costata could be a potential candidate to be used as a new antimalarial drug. | ||
| کلیدواژهها | ||
| Malaria؛ Castanopsis costata؛ Antimalarial drugs؛ Plasmodium berghei | ||
| مراجع | ||
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Alkandahri MY, Nisriadi L, Salim E. 2016. Secondary metabolites and antioxidant activity of methanol extract of Castanopsis costata leaves. Pharmacol Clin Pharm Res, 1: 98-102.
Alkandahri MY, Siahaan PN, Salim E, Fatimah C. 2018. Anti inflammatory activity of cep-cepan leaves (Castanopsis costata (Blume) A.DC). Int J Current Med Sci, 8: 424-429.
Bantie L, Assefa S, Teklehaimanot T, Engidawork E. 2014. In vivo antimalarial activity of the crude leaf extract and solvent fractions of croton macrostachyus hocsht. (Euphorbiaceae) against Plasmodium berghei in mice. BMC Complement Altern Med, 14: 2-10.
Bero J, Quetin-Leclercq J. 2011. Natural products published in 2009 from plants traditionally used to treat malaria. Plant Med, 77: 631-40.
Biagini GA, O’Neill, Nzila PM, Ward SA. 2003. Antimalarial chemotherapy: young guns or back to the future. Trends Parasitol, 19: 479-487.
Bilia AR, Melilo de Malgalhaes P, Berganzi MC, Vincieri FF. 2006. Simultaneous analysis of artemisinin and flavonoids or several extract of Artimisia annua L. obtained from a Commercial Sample and Selected Cultivar. J Phytomed, 13: 487-493.
Builders MI, Wannang NN, Ajoku GA, Builders PF, Orisadipe A, Aguiyi JC. 2010. Evaluation of antimalarial potential of Vernonia ambigua kotschy and peyr (Asteraceae). Int J Pharmacol, 18: 1-9.
Burke E, Deasy J, Hasson R, McCormack R, Randhawa V, Walsh P. 2003. Antimalarial drug from nature. J Trinity Student Med: 1-8.
Cai S, Risinger AL, Nair S, Peng J, Anderson TJC, Du L, Powell DR, Mooberry SL, Cichewicz RH. 2016. Identification of compounds with efficacy against malaria parasites from common north american plants. J Nat Prod, 79: 490-498.
Cooke B, Mohandas N, Coppel R. 2001. The malaria-infected red blood cell: structural and functional changes. Advan Parasitol,50: 1-86.
Elfahmi Woerdenbag HJ, Kayser O. 2014. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med 4: 51-73.
Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. 2004. Antimalarial drug discovery: Efficacy models for compound screening. Nat Rev Drug Disc, 3: 509-520.
Frolich S, Schuberth C, Bienzle U, Siems KJ. 2005. In vitro Antiplasmodial activity of prenylated chalcon derivates and their interaction with haemin. J Antimicro Chemother, 55: 883-887.
Hayati EK, Jannah A, Ningsih R. 2012. Compounds identification and in vivo antimalarial activity of ethyl acetate extract from anting-anting plant (Acalypha Indica L.). Molekul, 7: 20-32.
Hilou A, Nacoulma OG, Guiguemde TR. 2006. In vivo antimalarial activities of extracts Amaranthus spinosus L. and Boerhaavia erecta L. in mice. J Ethnopharmacol, 103: 236-240.
Kim K, Lee S, Jung S, Park H, Shinkilt Y, Kim BK. 2003. Antioxidant activities of the extracts from the herbs of Artemisia apiacea. J Ethnopharmacol, 85: 69-72.
Kirk, K. 2001. Membran transport in the malaria infected erythrocyte. Physol. Review, 81: 495-537.
Kirk, K. 2004. Channels and transporters as drug targets in the plasmodium-infected erythrocyte. J Acta Trop, 89: 285-298.
Knight DJ and Peters W. 1980. The antimalarial action of N-benzyloxy dihydrotriazines: The action of cycolguanil (BRL50216) against rodent malaria and studies on its mode of action. Ann Trop Med Parasitol, 74:393-404.
Laphookhieo S, Maneerat W, Koysomboon S. 2009. Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense. Molecule, 14: 1389-1395.
Meschnick SR, Taylor TE, Kamchonwongpaisan S. 1996. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol Rev, 60: 301-315.
Mustofa. 2003. Molekul antimalaria alami: potensi dan tantangan pengembangannya sebagai obat baru untuk malaria. Trad Med J, 8: 8-18.
Nogueira CR, Lopes ML. 2011. Antiplasmodial natural products. Molecules, 16: 2146-2190.
Nurtjahja K, Kelana TB, Suryanto D, Priyani N, Rio G, Putra DP, Arbain D. 2013. Antimicrobial activity of endemic herbs from tangkahan conservation forest north sumatera to bacteria and yeast. Hayati J Biosci, 20: 177-181.
Pan WH, Xu XY, Shi N, Tsang SW, Zhang HJ. 2018. Antimalarial activity of plant metabolites. Int J Mol Sci, 19: 1-40.
Pouplin JN, Tran TH, Dolecek C, Phan TA, Farrar J, Carron P, Bodo B, Grellier P. 2007. Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from south vietnam. J Ethnopharmacol, 109: 417-427.
Yadav RNS, Agarwala M. 2011. Phytochemical analysis of some medicinal plants. J Phytol, 3: 10-14.
Salim E, Fatimah C, Fanny DY. 2017.
Analgetic activity of cep-cepan (Saurauia Cauliflora Dc.) leaves extract. J Nat, 17: 31-38.
Saxena S, Pant N, Jain DC, Bhakuni RS. 2003. Antimalarial agent from Plant Source. Curr Sci, 85: 1314-29.
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