سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Esmaeili, Saeid, Shahali, Maryam, Kordjamshidi, Alireza, Torkpoor, Zahra, Namdari, Farshad, Samandari, Saeed Saber-, Ghadiri Nejad, Mazyar, Khandan, Amirsalar. (1398). An artificial blood vessel fabricated by 3D printing for pharmaceutical application. , 6(3), 183-194. doi: 10.22038/nmj.2019.06.00005
Saeid Esmaeili; Maryam Shahali; Alireza Kordjamshidi; Zahra Torkpoor; Farshad Namdari; Saeed Saber- Samandari; Mazyar Ghadiri Nejad; Amirsalar Khandan. "An artificial blood vessel fabricated by 3D printing for pharmaceutical application". , 6, 3, 1398, 183-194. doi: 10.22038/nmj.2019.06.00005
Esmaeili, Saeid, Shahali, Maryam, Kordjamshidi, Alireza, Torkpoor, Zahra, Namdari, Farshad, Samandari, Saeed Saber-, Ghadiri Nejad, Mazyar, Khandan, Amirsalar. (1398). 'An artificial blood vessel fabricated by 3D printing for pharmaceutical application', , 6(3), pp. 183-194. doi: 10.22038/nmj.2019.06.00005
Esmaeili, Saeid, Shahali, Maryam, Kordjamshidi, Alireza, Torkpoor, Zahra, Namdari, Farshad, Samandari, Saeed Saber-, Ghadiri Nejad, Mazyar, Khandan, Amirsalar. An artificial blood vessel fabricated by 3D printing for pharmaceutical application. , 1398; 6(3): 183-194. doi: 10.22038/nmj.2019.06.00005

An artificial blood vessel fabricated by 3D printing for pharmaceutical application

Nanomedicine Journal
مقاله 5، دوره 6، شماره 3، مهر 2019، صفحه 183-194    اصل مقاله (1.45 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2019.06.00005
نویسندگان
Saeid Esmaeili1؛ Maryam Shahali2؛ Alireza Kordjamshidi3؛ Zahra Torkpoor4؛ Farshad Namdari5؛ Saeed Saber- Samandari1؛ Mazyar Ghadiri Nejad6؛ Amirsalar Khandan* 1
1New Technologies Research Center, Amirkabir University of Technology, Tehran, 15875-4413, Iran
2Department of Quality Control, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran
3Department of Pharmacy, Eastern Mediterranean University, Gazimagusa, TRNC, via Mersin 10, Turkey
4Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5Department of Urology, AJA University of Medical Sciences, Tehran, Iran
6Department of Industrial Engineering, Eastern Mediterranean University, Gazimagusa, TRNC, Via Mersin 10, Turkey
چکیده
Objective(s): Cardiovascular diseases (CVDs) are the leading cause of mortality in the elderly. A common medical procedure for the treatment of CVDs is the replacement of the blocked or narrowed arteries, which is currently the optimal vascular transplant associated with autograft transplantation. In general, the saphenous veins and radial arteries in the mammary gland are considered to be the selective vessels for vascular substitution. In many cardiac patients, artificial blood vessels (ABVs) are not used for several reasons, including the age of the patient, small size of the veins, previous impressions, and abnormally. Therefore, the consideration of vascular substitute demands is inevitable, especially regarding vascular transplantation with very small diameters and availability of proper alternatives. The present study aimed to develop a novel artificial bio-composite blood vessel using polymer-reinforced and bioceramic nanoparticles.
Materials and Methods: The biomechanics and chemical properties of artificial vessels have been investigated to be used in coronary artery bypassing in atherosclerosis as a soft tissue engineering procedure. In this study, thermoplastic polyurethane (TPU) composed of nanocrystalline hydroxyapatite (HA) nanopowder was prepared using the extrusion technique to construct the ABVs. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to investigate the optimum specimen. An important feature of the ABVs was the ability to find the elastic modulus, wettability, and porosity of the veins, which were assessed by fused deposition modeling and 3D printing.
Results: The sample containing five wt% of HA had superior mechanical and biological features over the pure sample.
Conclusion: According to the results, the narrowed arteries composed of TPU composite with nanocrystalline HA nanopowder had proper chemical stability and mechanical characteristics.
کلیدواژه‌ها
Artificial vessel؛ 3D Printing؛ Flexible polymer؛ Bioceramic؛ Cardiovascular Diseases
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