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Hamzian, Nima, Hashemi, Maryam, Ghorbani, Mahdi, Ramezani, Mohammad, Bahreyni Toosi, Mohammad Hossein. (1397). Study of multifunctional PLGA-SPION nanoparticles loaded with Gemcitabine as radiosensitizer. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 432-432. doi: 10.22038/ijmp.2018.13119
Nima Hamzian; Maryam Hashemi; Mahdi Ghorbani; Mohammad Ramezani; Mohammad Hossein Bahreyni Toosi. "Study of multifunctional PLGA-SPION nanoparticles loaded with Gemcitabine as radiosensitizer". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 432-432. doi: 10.22038/ijmp.2018.13119
Hamzian, Nima, Hashemi, Maryam, Ghorbani, Mahdi, Ramezani, Mohammad, Bahreyni Toosi, Mohammad Hossein. (1397). 'Study of multifunctional PLGA-SPION nanoparticles loaded with Gemcitabine as radiosensitizer', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 432-432. doi: 10.22038/ijmp.2018.13119
Hamzian, Nima, Hashemi, Maryam, Ghorbani, Mahdi, Ramezani, Mohammad, Bahreyni Toosi, Mohammad Hossein. Study of multifunctional PLGA-SPION nanoparticles loaded with Gemcitabine as radiosensitizer. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 432-432. doi: 10.22038/ijmp.2018.13119

Study of multifunctional PLGA-SPION nanoparticles loaded with Gemcitabine as radiosensitizer

Iranian Journal of Medical Physics
مقاله 415، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 432-432
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.13119
نویسندگان
Nima Hamzian* 1؛ Maryam Hashemi2؛ Mahdi Ghorbani3؛ Mohammad Ramezani* 4؛ Mohammad Hossein Bahreyni Toosi5
1Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Nanotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.
3Biomedical Engineering and Medical Physics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
5Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Abstract
This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously into poly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system. The physicochemical characteristics of the nanoparticles (NPs) were studied. The dose enhancement ratio (DER) of various treatment groups was calculated and compared using human breast cancer cell line (MCF-7). The DER for PLGA-SPION-Gem was the highest at 1 Gy 60Co (3.18). Cumulative effect from simultaneous use of two radiosensitizer (Gem and SPIONs) was observed. Thus, we have successfully developed PLGA NPs loaded with gemcitabine and SPION as a radiosensitizer system which potentially could be used in radiotherapy.
کلیدواژه‌ها
Multifunctional drug delivery system؛ SPION-PLGA؛ Gemcitabine؛ Radiotherapy؛ Radiosensitizer
آمار
تعداد مشاهده مقاله: 407