Shirmardi, Seyed Pezhman, Erfani, Mostafa, Zare Mirakabadi, Abbas, Mirzaei, Hamidreza, Mola, Masoud, Pezham, Mohammad Hasan, Karamivand, Meysam, Saniei, Elham. (1397). Radiolabeling the Peptides extracted from Scorpion venom (ICD-85) with 99mTc as treatment and imaging agent for cancer. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 357-357. doi: 10.22038/ijmp.2018.13021
Seyed Pezhman Shirmardi; Mostafa Erfani; Abbas Zare Mirakabadi; Hamidreza Mirzaei; Masoud Mola; Mohammad Hasan Pezham; Meysam Karamivand; Elham Saniei. "Radiolabeling the Peptides extracted from Scorpion venom (ICD-85) with 99mTc as treatment and imaging agent for cancer". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 357-357. doi: 10.22038/ijmp.2018.13021
Shirmardi, Seyed Pezhman, Erfani, Mostafa, Zare Mirakabadi, Abbas, Mirzaei, Hamidreza, Mola, Masoud, Pezham, Mohammad Hasan, Karamivand, Meysam, Saniei, Elham. (1397). 'Radiolabeling the Peptides extracted from Scorpion venom (ICD-85) with 99mTc as treatment and imaging agent for cancer', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 357-357. doi: 10.22038/ijmp.2018.13021
Shirmardi, Seyed Pezhman, Erfani, Mostafa, Zare Mirakabadi, Abbas, Mirzaei, Hamidreza, Mola, Masoud, Pezham, Mohammad Hasan, Karamivand, Meysam, Saniei, Elham. Radiolabeling the Peptides extracted from Scorpion venom (ICD-85) with 99mTc as treatment and imaging agent for cancer. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 357-357. doi: 10.22038/ijmp.2018.13021

Radiolabeling the Peptides extracted from Scorpion venom (ICD-85) with 99mTc as treatment and imaging agent for cancer

Iranian Journal of Medical Physics
مقاله 350، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 357-357
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.13021
نویسندگان
Seyed Pezhman Shirmardi* 1؛ Mostafa Erfani1؛ Abbas Zare Mirakabadi2؛ Hamidreza Mirzaei3؛ Masoud Mola1؛ Mohammad Hasan Pezham1؛ Meysam Karamivand1؛ Elham Saniei4
1Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
2Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Agriculture Research Education and Extension Organization, Karaj, Iran
3Department of Radiation Oncology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Islamic Azad University, Central Tehran Branch
چکیده
Introduction: Venoms are a mixture of proteins and peptides which can be used for fighting cancers. They can affect the exposed fibers and the muscles directly or through motor nerves, causing neuromuscular intoxication. ICD-85 is a combination of three poly-peptides derived from the venoms of an Iranian brown snake and a yellow scorpion.
Materials and Methods: Technetium-99m was obtained from a 99Mo/99mTc generator. Venom (ICD-85) was provided by Razi Vaccine and Serum Research Institute of Iran. Labeling of this venom was achieved with Technetium-99m. Labeled ICD-85 was injected into mice to determine the organ targets and excretion pathway.
Results: Results show that the radiolabeling yield of the radio-venom is acceptable. The biodistribution study shows that the organs of liver, kidney and tumor are the targets of ICD venom. Also moderate clearance of the complex from blood was seen.
 
Conclusion: The results suggest that 99mTc radiolabeling of venom (ICD-85) may be a good tool for in-vivo studies and is an excellent approach to follow the process of biodistribution and kinetics of toxins for cancer imaging and treatment.
کلیدواژه‌ها
Cancer؛ venom؛ Radiolabeling؛ Technetium-99m
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