Gastro-protective effect of Biebersteinia multifida root hydro-methanolic extract in rats with ethanol-induced peptic ulcer | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 1، دوره 9، شماره 5، آذر و دی 2019، صفحه 410-418 اصل مقاله (407.15 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2019.12902 | ||
| نویسندگان | ||
| Mahdi Raeesi1؛ Narges Eskandari-Roozbahani1؛ Tahoora Shomali* 2 | ||
| 1Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 2Division of Pharmacology and Toxicology, department of basic sciences, school of veterinary medicine, shiraz university, shiraz, iran | ||
| چکیده | ||
| Objective: Biebersteinia multifida is one of the native plants of Iran and its root is used in folk medicine. This study aimed to evaluate the gastro-protective effect of the hydro-methanolic extract of this plant's roots against ethanol-induced gastric ulcer in rats. Materials and Methods: The following five groups of seven rats were included in this study: control (C), gastric ulcer (GU), control omeprazole (CO) and two treatment groups (the latter 3 groups were rats with gastric ulcer that orally received omeprazole, 20 mg/kg, or the root extract at 150 and 300 mg/kg (BM 150and BM 300, respectively) 1 hour before ulcer induction). One hour after ulcer induction, blood sampling was performed and after sacrificing animals, the stomachs were immediately removed. Gastric mucosal injury was studied grossly to determine the number and area of gastric ulcers. The level of nitric oxide (NO) and total antioxidant capacity (TAC) in gastric mucosa as well as serum TNF-α were determined. Results: In GU group, severe mucosal injuries were observed (pThe lesions in CO and treatment groups were much milder than GU group by regarding ulcer area and number (p In treated (BM 150 and BM 300) groups, the gastric mucosal TAC and NO level were significantly higher than GU group (p Conclusion: B. multifida possesses gastro-protective effects against ethanol-induced ulcer model; this effect is at least partly related to plant’s antioxidant and NO production accelerating properties. | ||
| کلیدواژهها | ||
| Biebersteinia multifida؛ Peptic ulcer؛ Rat؛ Antioxidant؛ Anti-inflammatory | ||
| مراجع | ||
|
Abdallah IZ, Khattab HA, Heeba GH. 2011. Gastroprotective effect of Cordia Myxa L. fruit extract against indomethacin-induced gastric ulceration in rats. Life Sci, 8:433-445.
Aboutorabi H. 2001. Ethnobotanic and phytochemical study of plants in Rouin region. Pharma Thesis. Tehran University of Medical Sciences, Tehran, Iran.
Arifkhodzhaev AO, Arifkhodzhaev KA, Kondratenko ES. 1985. Polysaccharides of saponin-bearing plants. II. Isolation and characterization of the polysaccharides of Biebersteinia multifidi. Chem Nat Compd, 21:714–716.
Arifkhodzhaev AO, Rakhimov D. 1993. Polysaccharides of saponin-bearing plants.IV. Structure of glucans A, B, and C of Biebersteinia multifidi.Chem Nat Compd, 29:151–153.
Arifkhodzhaev AO, Rakhimov DA. 1994. Polysaccharides of saponin-bearing plants.V. Structural investigation of glucans A, B, and C and their oligosaccharides from Biebersteinia multifida plants. Chem Nat Compd, 30:655–660.
Amin G. 1991. Popular medicinal plants of Iran. 1st edition. Research Deputy, Ministry of Health, Treatment and Medical Education. Tehran, Iran.
Amirghofran Z. 2010. Medicinal plants as immunosuppressive agents in traditional Iranian medicine. Iran J Immunol, 7:65–73.
Bi WP, Man HB, Man MQ. 2014. Efficacy and safety of herbal medicines in treating gastric ulcer: a review. World J Gastroenterol. 20:17020-17028.
Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. 2003. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem. 278:10993-1001.
Brzozowski T, Konturek PC, Konturek SJ, Kwiecién S, Pajdo R, Brzozowska I, Hahn EG. 1998. Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat. J Clin Gastroenterol, 27: 125-137.
Cadirci E, Suleyman H, Aksoy H, Halici Z, Ozgen U, Koc A, Ozturk N. 2007. Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. ChemBiol Interact,170: 40-48.
Cho CH. 2001. Current roles of nitric oxide in gastrointestinal disorders.J Physiol Paris, 95: 253-256.
Choi JI, Raghavendran HR, Sung NY, Kim JH, Chun BS, Ahn DH, Choi HS, Kang KW, Lee JW. 2010. Effect of fucoidan on aspirin-induced stomach ulceration in rats.Chem Biol Interact, 183: 249-254.
Chou SP. 1994. An examination of the alcohol consumption and peptic ulcer association: Results of a national survey. Alcohol Clin Exp Res, 18:149–153.
Christenhusz MJM, Byng JW. 2016. The number of known plants species in the world and its annual increase. Phytotaxa. 261: 201–217.
De Souza AES, Filho VC, Niero R, Clasen BK, Balogun SO, Oliveira MDT. 2011. Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. In animal models. J Ethnopharmacol., 134: 630–636.
Du Y, Zhao W, Lu L, Zheng J, Hu X, Yu Z, Zhu L. 2013. Study on the anti-ulcer effects of Veronica strumaxillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α (TNF-α) and endothelin-1 (ET-1). Asian Pac J Trop Biomed, 3:925-930.
Everhart JE, Byrdholt D, Sonnenberg A. 1998. Incidence and risk factors for self-reported peptic ulcer disease in the United States. Am J Epidemiol., 147:529–536.
Farsam H, Amanlou M, Dehpour AR, Jahaniani F. 2000. Anti-inflammatory and analgesic activity of Biebersteinia multifida DC. root extract. J Ethnopharmacol, 71: 443-447.
Ghodrati N, Asili J, Mohammadi Sani A, Fazli Bazzaz BS. 2012. Evaluation of Antibacterial activities of different roots extracts of Biebersteinia multifida DC. Journal of North Khorasan University of Medical Sciences (Natural Products & Medicinal Plants Supplementary), 4:149-154.
Handa O, Yoshida N, Fujita N, Tanaka Y, Ueda M, Takagi T, Kokura S, Naito Y, Okanoue T, Yoshikawa T. 2006. Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors. Inflamm Res, 55:476-480
Hernandez-Munoz R, Montiel-Ruiz C, Vazquez-Martinez O. 2000. Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab Invest, 80:1161-1169.
Kedika RR, Souza RF, Spechler SJ. 2009. Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci, 54: 2312-2317.
Keshavarzi Z, Nazari M, Razmi Z, Behnamfar M. 2018. The Modulatory effects of aqueous extract of the plant biebersteinia multifida on the gastric acid level and intestinal cytokines in ulcerative colitis model. JBUMS. 20:7-13.
Konturek SJ, KonturekPC, and Brzozowski T. 2005. Prostaglandins and ulcer healing. J Physiol Pharmacol, 56(5):5–31.
Kurbanov D, Zharekeev B. 1974. Alkaloid of Biebersteinia multifida and Peganumharmala from the karakalpak ASSR Russian [Abstract]. Him Prir Soedin, 5: 685-686
Le QL, Zhang J, Xu QZ, Gao HY. 2001. Role of nitric oxide in omeprazole protection of the gastric mucosa in rats. Di Yi Jun Yi Da Xue Xue Bao, 21:926-928.
Li WF, Hao DJ, Fan T, Huang HM, Yao H, Niu XF. 2014. Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice.Chem Biol Interact, 208:18-27.
Monsef-Esfahani HR, Amini M, Goodarzi N, Saiedmohammadi F, Hajiaghaee R, Faramarzi MA, Tofighi Z, Ghahremani MH. 2013. Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice. Daru, 21:51.
Mota KSDL, Pita JCLR, Estevam EC, Medirose VM, Tavares JF, Agra MF, Diniz MFFM, Silva MS, Batista LM. 2008. Evaluation of the toxicity and antiulcerogenic activity of the ethanol extract of Maytenus obtusifolia Mart. leaves. Rev Bras Farmacogn, 18: 441– 446.
Muellner AN. 2011. Biebersteiniaceae. In: Kubitzki K, The Families, and Genera of Vascular Plants, Flowering Plants Eudicots, pp. 72, Verlag Berlin, Springer.
Nabavi SF, Ebrahimzadeh MA, Nabavi SM, Eslami B, Dehpour A. 2010. Anti-hemolytic and antioxidant activities of Biebersteinia multifida. Eur Rev Med Pharmacol Sci, 14: 823-830.
Nakashita M, Suzuki H, Miura S, Taki T, Uehara K, Mizushima T, Nagata H, Hibi T. 2013. Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors. Dig Dis Sci, 58:354-362.
Oates PJ, Hakkinen JP. 1988. Studies on the mechanism of ethanol-induced gastric damage in rats.Gastroenterology, 94:10-21.
Pan LR, Tang Q, Fu Q, Hu BR, Xiang JZ, Qian JQ. 2005. Roles of nitric oxide in the protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin, 26:1334-1338.
Razvodovsky YE. 2006. Aggregate level association between alcohol and the peptic ulcer mortality rate. Alcoholism, 42: 61–68.
Repetto MG, Llesuy SF. 2002. Antioxidant properties of natural compounds used in popular medicine for gastric ulcer. Braz J Med Biol Res, 35:523-534.
Richardson CT. 1990. Role of aggressive factors in the pathogenesis of peptic ulcer disease. Scand J Gastroenterol, 174: 37–43.
Sannomiya M, Fonseca VB, Da Silva MA, Rocha LR, Dos Santos LC, Hiruma-Lima CA, Souza Brito AR, Vilegas W. 2005. Flavonoids and anti-ulcerogenic activity from Byrsonimacrassa leaves extracts. J Ethnopharmacol, 97:1–6.
Segawa K, Nakazawa S, Tsukamoto Y, Chujoh C, Yamao K, Hase S. 1987. Effect of omeprazole on gastric acid secretion in the rat: evaluation of dose, duration of effect, and route of administration. Gastroenterol Jpn, 22:413-418.
Shin JM, Sachs G. 2008. Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep, 10: 528–534.
Shomali T, Raeesi M, Eskandari-Roozbahani N. 2016. Zataria multiflora Boiss. essential oil against ethanol-induced gastric ulcer in rats by antioxidant properties and an increase in nitric oxide production. J Herb Med Pharmacol, 5: 143-148.
Tepperman BL, Soper BD. 1994. Nitric oxide synthase induction and cytoprotection of rat gastric mucosa from injury by ethanol. Can J PhysiolPharmacol,72:1308-1312. | ||
|
آمار تعداد مشاهده مقاله: 11,791 تعداد دریافت فایل اصل مقاله: 5,541 |
||