Graphene Quantum Dots-Coated Bismuth Nanoparticles for X-ray CT Imaging-Guided Photothermal therapy of Cancer Cells | ||
| Iranian Journal of Medical Physics | ||
| مقاله 248، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 250-250 | ||
| نوع مقاله: Conference Proceedings | ||
| شناسه دیجیتال (DOI): 10.22038/ijmp.2018.12886 | ||
| نویسندگان | ||
| Samireh Badrigilan1؛ Behrouz Shaabani2؛ Nahideh Ghareh aghaji3؛ Asghar Mesbahi* 4 | ||
| 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Department of medical physics, Faculty of Medical, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Department of Inorganic Chemistry, Faculty of Chemistry, Tabriz University, Tabriz, Iran | ||
| 3Department of Radiology, Faculty of Paramedical, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| 4Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Department of medical physics, Faculty of Medical, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| چکیده | ||
| Introduction: Theranostic nanoparticles, which integrate both diagnostic and therapeutic capabilities into one nanoagent, has great promise to ablate more effective tumoral tissue by optimizing and real-time monitoring treatment interventions, as well as monitoring therapeutic response to corresponding effect. Multifunctional theranostic nanoagent based on graphene quantum dots (GQDs)-coated Bi nanohybrids (GQDs-Bi NPs) was developed and investigate their multimodal imaging and PTT performance. Materials and Methods: The GQDs-Bi NPs were fabricated by utilizing simple two-step synthesis: GQDs as shell and Bi NPs as core in presence of GQDs. By hemolysis and MTT test, blood compatibility and cellular toxicity of GQDs-Bi NPs were examined. For phantom CT imaging, the GQDs-Bi NPs aqueous solutions at various concentrations of Bi element scanned by a clinical CT scanner (GE HiSpeed) (160 mA, 80,120 and140 kV). The corresponding CT values (HU) were measured by imageJ software. To evaluate the photothermal effect, the GQDs-Bi NPs dispersions at different concentrations of active Bi metal were irradiated with an 808 nm-NIR-laser (1.7 W·cm-2) for 10 min and a thermocouple probe was used to record the temperature of suspensions. Results: The GQDs-Bi NPs showed satisfactory cytotoxicity and hemolysis behavior. The heavy metal Bi component (Z=83) in the GQDs-Bi NPs produced much higher Hounsfield units (173 HU) than the contrast agents based on small molecules iodine (134 HU), corresponding, 1 mg Bi/ml provided an equivalent X-ray attenuation as dotarem contain of 1.5 mg/mL Iodine. A strong and steady absorbance was found for GQDs-Bi NPs in the whole NIR range, as well as high photo-to-thermal conversion capability and photostability, encouraging a high antitumor PTT efficiency. The GQDs-Bi NPs could successfully kill in vitro MCF-7 and HeLa cancer cells under NIR irradiation with killing effect dependent on dose compared to those received laser only (3.0%). Conclusion: GQDs-Bi nanotheranostic may become an effective tool for CT imaging-guided therapy for personalized cancer treatment. | ||
| کلیدواژهها | ||
| Bi nanotheranostic؛ computed tomography imaging؛ photothermal therapy؛ in vitro | ||
|
آمار تعداد مشاهده مقاله: 625 |
||
| تعداد نشریات | 29 |
| تعداد شمارهها | 2,324 |
| تعداد مقالات | 24,864 |
| تعداد مشاهده مقاله | 82,812,701 |
| تعداد دریافت فایل اصل مقاله | 45,865,545 |