khosravi, Hossein, Hashemi, Bijan, Mahdavi, Seyed Rabi. (1397). Investigation of the dose enhancement effect due to gold nanoparticles at 18 MV radiotherapy using MAGIC-f and Monte Carlo methods Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 249-249. doi: 10.22038/ijmp.2018.12885
Hossein khosravi; Bijan Hashemi; Seyed Rabi Mahdavi. "Investigation of the dose enhancement effect due to gold nanoparticles at 18 MV radiotherapy using MAGIC-f and Monte Carlo methods Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 249-249. doi: 10.22038/ijmp.2018.12885
khosravi, Hossein, Hashemi, Bijan, Mahdavi, Seyed Rabi. (1397). 'Investigation of the dose enhancement effect due to gold nanoparticles at 18 MV radiotherapy using MAGIC-f and Monte Carlo methods Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 249-249. doi: 10.22038/ijmp.2018.12885
khosravi, Hossein, Hashemi, Bijan, Mahdavi, Seyed Rabi. Investigation of the dose enhancement effect due to gold nanoparticles at 18 MV radiotherapy using MAGIC-f and Monte Carlo methods Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 249-249. doi: 10.22038/ijmp.2018.12885

Investigation of the dose enhancement effect due to gold nanoparticles at 18 MV radiotherapy using MAGIC-f and Monte Carlo methods Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field

Iranian Journal of Medical Physics
مقاله 247، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 249-249
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.12885
نویسندگان
Hossein khosravi* 1؛ Bijan Hashemi2؛ Seyed Rabi Mahdavi3
1Department of Radiology, Faculty of Paramedical, Hamadan University of Medical Sciences, Hamadan, Iran.
2Department of Medical Physics, Tarbiat Modares University, Tehran, Iran.
3Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran.
چکیده
Introduction:
Normoxic MAGIC-f polymer gels are established dosimeters used for three dimensional dos uantifications in radiotherapy. The high atomic number nanoparticles such as gold are nov adiosensitizers used to enhance doses delivered to tumors. The aim of this study was t vestigate the effect of gold nanoparticles (GNPs) in enhancing percentage depth doses (PDD ithin the MAGIC-f gel exposed to linac high energy photon beams (18MV).
 
Materials and methods:
The MAGIC-f gel was fabricated based on its standard composition with some modifications an oured into falcon tubes. The PDDs in the tubes containing the gel were calculated using a commo onte Carlo code (MCNPX) followed by experimental verifications. Then, the GNPs with a verage diameter of 15 nm and a concentration of 0.1 mM were embedded in the gel, poured int milar falcon tubes and irradiated to 18 MV beams of a Varian 2100 linac. Finally, simila xperimental and Monte Carlo (MC) calculations were conducted to determine the effect of usin e GNPs on some dosimetric parameters of interest.
Results:
The results of experimental measurements and simulated MC calculations showed a dos nhancement factor (DEF) of 1.12±0.07 and 1.13±0.06 respectively due to the use of the GNP hen exposed to 18 MV linac energies.
Conclusion:
The results indicated that the fabricated MAGIC-f gel could be recommended as a suitable tool fo ree dimensional dosimetric investigations at high energy radiotherapy procedures wherein th NPs are used.
کلیدواژه‌ها
MAGIC-f gel dosimetry؛ GNPs؛ Monte Carlo method؛ 18 MV radiotherapy؛ dose enhancement factor
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