سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mehri, Keivan, Banan Khojasteh, Seyed Mehdi, Farajdokht, Fereshteh, Zavvari Oskuye, Zohreh, Ebrahimi, Hadi, Diba, Rogaye, Bayandor, Parvin, Hosseindoost, Maryam, Babri, Shirin. (1398). Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats. , 22(6), 637-642. doi: 10.22038/ijbms.2019.34158.8123
Keivan Mehri; Seyed Mehdi Banan Khojasteh; Fereshteh Farajdokht; Zohreh Zavvari Oskuye; Hadi Ebrahimi; Rogaye Diba; Parvin Bayandor; Maryam Hosseindoost; Shirin Babri. "Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats". , 22, 6, 1398, 637-642. doi: 10.22038/ijbms.2019.34158.8123
Mehri, Keivan, Banan Khojasteh, Seyed Mehdi, Farajdokht, Fereshteh, Zavvari Oskuye, Zohreh, Ebrahimi, Hadi, Diba, Rogaye, Bayandor, Parvin, Hosseindoost, Maryam, Babri, Shirin. (1398). 'Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats', , 22(6), pp. 637-642. doi: 10.22038/ijbms.2019.34158.8123
Mehri, Keivan, Banan Khojasteh, Seyed Mehdi, Farajdokht, Fereshteh, Zavvari Oskuye, Zohreh, Ebrahimi, Hadi, Diba, Rogaye, Bayandor, Parvin, Hosseindoost, Maryam, Babri, Shirin. Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats. , 1398; 22(6): 637-642. doi: 10.22038/ijbms.2019.34158.8123

Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats

Iranian Journal of Basic Medical Sciences
مقاله 8، دوره 22، شماره 6، شهریور 2019، صفحه 637-642    اصل مقاله (743.33 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.34158.8123
نویسندگان
Keivan Mehri1؛ Seyed Mehdi Banan Khojasteh2؛ Fereshteh Farajdokht3؛ Zohreh Zavvari Oskuye1؛ Hadi Ebrahimi1؛ Rogaye Diba1؛ Parvin Bayandor1؛ Maryam Hosseindoost1؛ Shirin Babri* 1
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Iran
3Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Objective(s): Maternal high-fat diet (HFD) consumption has been linked to metabolic disorders and reproductive dysfunctions in offspring. Troxerutin (TRO) has anti-hyperlipidemic, anti-oxidant, and anti-inflammatory effects. This study examined the effects of TRO on apelin-13, its receptors mRNA and ovarian histological changes in the offspring of HFD fed rats.
Materials and Methods: Female Wistar rats were randomly divided into control diet (CD) or HFD groups and received these diets for eight weeks. After mating, dams were assigned into four subgroups: CD, CD + TRO, HFD, and HFD + TRO, and received their respective diets until the end of lactation. Troxerutin (150 mg/kg/day) was gavaged in the CD + TRO and HFD + TRO groups during pregnancy. On the postnatal day (PND) 21 all female offspring were separated and fed CD until PND 90. On PND 90 animals were sacrificed and ovarian tissue samples were collected for further evaluation.
Results: Results showed that HFD significantly decreased serum apelin-13 in the female offspring of the HFD dams, which was significantly reversed by TRO. Moreover, real-time polymerase chain reaction (PCR) analysis revealed that TRO treatment significantly decreased the ovarian mRNA expression of the apelin-13 receptor in the troxerutin-received offspring. Furthermore, histological examination revealed that TRO increased the number of atretic follicles in the ovaries of HFD+TRO offspring.
Conclusion: Maternal high fat feeding compromises ovarian health including follicular growth and development in the adult offspring and troxerutin treatment improved negative effects of maternal HFD on the apelin-13 level and ovarian development of offspring.
کلیدواژه‌ها
Apelin-13؛ APJ receptor؛ Maternal high-fat diet؛ Ovarian development؛ Troxerutin
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