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Burduk, Pawel, Sawicki, Piotr, Szylberg, Lukasz, Bodnar, Magdalena, Marszalek, Andrzej. (1398). Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma. , 31(3), 153-161. doi: 10.22038/ijorl.2018.27737.1905
Pawel Burduk; Piotr Sawicki; Lukasz Szylberg; Magdalena Bodnar; Andrzej Marszalek. "Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma". , 31, 3, 1398, 153-161. doi: 10.22038/ijorl.2018.27737.1905
Burduk, Pawel, Sawicki, Piotr, Szylberg, Lukasz, Bodnar, Magdalena, Marszalek, Andrzej. (1398). 'Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma', , 31(3), pp. 153-161. doi: 10.22038/ijorl.2018.27737.1905
Burduk, Pawel, Sawicki, Piotr, Szylberg, Lukasz, Bodnar, Magdalena, Marszalek, Andrzej. Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma. , 1398; 31(3): 153-161. doi: 10.22038/ijorl.2018.27737.1905

Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma

Iranian Journal of Otorhinolaryngology
مقاله 4، دوره 31، شماره 3، مرداد و شهریور 2019، صفحه 153-161    اصل مقاله (438.37 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2018.27737.1905
نویسندگان
Pawel Burduk* 1؛ Piotr Sawicki2؛ Lukasz Szylberg3؛ Magdalena Bodnar3؛ Andrzej Marszalek4
1Department of Otolaryngology,Oncology and Oral and Maxillofacial Surgery, Faculty of Health Sciences, Nicolaus Copernicus University in Toruń, Poland.
2Private ENT Practice, Bydgoszcz, Poland
3Department of Clinical Pathomorphology Collegium Medicum, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Poland
4Department of Oncologic Pathology, Poznan University of Medical Sciences and Greater Poland Oncology Center, Poznan, Poland
چکیده
Introduction:
Metalloproteinases and their tissue inhibitors play an important role in the metastases formation.
A multistage process of carcinogenesis requires the involvement of numerous enzymes and compounds that facilitate the expansion of tumor cells. The formation of metastases depends on both metalloproteinases and tissue inhibitors activation leading to the activation of neoangiogenesis. The changes of the expression in stromal and tumor proteins could be prognostic factors in patients with oropharyngeal squamous cell carcinoma.
 
Materials and Methods:
This study was conducted on a total of 34 patients with squamous cell carcinoma of the oropharynx divided into 2 groups, including 20 patients with neck metastasis and 14 patients without lymph node metastasis. Immunohistochemistry was performed with a standard protocol.
 
Results:
The results of the present analysis indicated a higher expression of metalloproteinases 2 in the stroma than in tumor with increasing tumor grade. The dynamics of changes in the expression of metalloproteinases showed the increase in metalloproteinases 2 and the decrease in metalloproteinases 9 depending on the tumor size. Dynamics of changes in the expression of tissue inhibitor 1 in the tumor stroma significantly increased with the tumor stage. In the assessment of nodal staging from N0 to N3, the expression of tissue inhibitor 1 and 2 were higher in the tumor tissues. The increase of metalloproteinases 2, tissue inhibitor 1 in the tumor, and metalloproteinases 9 in the stroma were characterized by a reduction in the odds ratio of patient’s survival.
 
Conclusion:
The complex evaluation of the expression of metalloproteinases and tissue inhibitors may be used for the prognosis of the patient’s survival.
کلیدواژه‌ها
Metalloproteinases؛ Oropharyngeal cancer؛ Survival؛ Tissue inhibitors
مراجع

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