Janati Esfahani, Azam, Mahdavi, Seied Rabi, Khoei, Samideh, Bakhshandeh, Mohsen, Rajabi, Ali. (1397). Capacitive Hyperthermia as an Alternative to Brachytherapy in Treatment of Human Prostate Cancer Cell. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 160-160. doi: 10.22038/ijmp.2018.12664
Azam Janati Esfahani; Seied Rabi Mahdavi; Samideh Khoei; Mohsen Bakhshandeh; Ali Rajabi. "Capacitive Hyperthermia as an Alternative to Brachytherapy in Treatment of Human Prostate Cancer Cell". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 160-160. doi: 10.22038/ijmp.2018.12664
Janati Esfahani, Azam, Mahdavi, Seied Rabi, Khoei, Samideh, Bakhshandeh, Mohsen, Rajabi, Ali. (1397). 'Capacitive Hyperthermia as an Alternative to Brachytherapy in Treatment of Human Prostate Cancer Cell', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 160-160. doi: 10.22038/ijmp.2018.12664
Janati Esfahani, Azam, Mahdavi, Seied Rabi, Khoei, Samideh, Bakhshandeh, Mohsen, Rajabi, Ali. Capacitive Hyperthermia as an Alternative to Brachytherapy in Treatment of Human Prostate Cancer Cell. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 160-160. doi: 10.22038/ijmp.2018.12664

Capacitive Hyperthermia as an Alternative to Brachytherapy in Treatment of Human Prostate Cancer Cell

Iranian Journal of Medical Physics
مقاله 160، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 160-160
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.12664
نویسندگان
Azam Janati Esfahani* 1؛ Seied Rabi Mahdavi2؛ Samideh Khoei3؛ Mohsen Bakhshandeh4؛ Ali Rajabi5
1Department of Medical Biotechnology, School of Paramedical Sciences, Qazvin University of Medical Sciences, Iran.
2Radiation Biology Research Center, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
4Radiology & Radiotherapy department- Para Medical Faculty- Shahid Beheshti University of Medical sciences, Tehran, Iran.
5Radiation Medicine Engineering Department, Shahid Beheshti University, Tehran, Iran
چکیده
Introduction: The aim of this study was the evaluation of induced DNA damages of human prostate cancer cells, DU-145, treated with a combination of radiofrequency capacitive hyperthermia (HT) and teletherapy (EBRT) compared to a combination of teletherapy with high dose rate brachytherapy (BR).
 
Materials and Methods: DU-145 cells were cultured as spheroids in 300-micron diameter. Then the following treatments were conducted: a) EBRT at doses of either 2Gy or 4Gy of photon 15MV, b) HT for 30, 60, and 90 minutes’ duration at 43°C from a 13.56MHz radiofrequency capacitive heating device (Celsius TCS), c) BR with Ir-192 seed at doses of either 2Gy or 5.5Gy, d) The mentioned HT followed by EBRT (HT+EBRT) and e) EBRT followed by BR (EBRT+BR). Alkaline comet assay was performed to measure tail moment.
Results: The induced DNA damages of DU-145 cells treated by adding HT to EBRT compared with EBRT alone, showed a significant enhancement; 3.28 and 5.14 times respectively for 30 and 60 minutes HT. By plotting dose-response curves, we could find a range of doses, which create radiobiological iso-effect in HT+EBRT and EBRT+BR treatments.
Conclusion: This study suggests that about DNA damages of DU-145 cells, HT+EBRT could partly be considered as an alternative to EBRT+BR.
کلیدواژه‌ها
Prostate cancer؛ hyperthermia؛ brachytherapy؛ teletherapy؛ comet assay
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