Ghoreshi, Fatemeh Sadat, Beik, Jaber, Shiri, Issac, Keshavarzi, Keikhosro, Mahdavi, Seyed Rabee Mahdi. (1397). Effect of gold nanoparticles on dose enhancement of 6 Mv X-rayin MAGIC_f polymer gel dosimeter. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 114-114. doi: 10.22038/ijmp.2018.12603
Fatemeh Sadat Ghoreshi; Jaber Beik; Issac Shiri; Keikhosro Keshavarzi; Seyed Rabee Mahdi Mahdavi. "Effect of gold nanoparticles on dose enhancement of 6 Mv X-rayin MAGIC_f polymer gel dosimeter". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 114-114. doi: 10.22038/ijmp.2018.12603
Ghoreshi, Fatemeh Sadat, Beik, Jaber, Shiri, Issac, Keshavarzi, Keikhosro, Mahdavi, Seyed Rabee Mahdi. (1397). 'Effect of gold nanoparticles on dose enhancement of 6 Mv X-rayin MAGIC_f polymer gel dosimeter', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 114-114. doi: 10.22038/ijmp.2018.12603
Ghoreshi, Fatemeh Sadat, Beik, Jaber, Shiri, Issac, Keshavarzi, Keikhosro, Mahdavi, Seyed Rabee Mahdi. Effect of gold nanoparticles on dose enhancement of 6 Mv X-rayin MAGIC_f polymer gel dosimeter. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 114-114. doi: 10.22038/ijmp.2018.12603

Effect of gold nanoparticles on dose enhancement of 6 Mv X-rayin MAGIC_f polymer gel dosimeter

Iranian Journal of Medical Physics
مقاله 114، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 114-114
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.12603
نویسندگان
Fatemeh Sadat Ghoreshi؛ Jaber Beik؛ Issac Shiri؛ Keikhosro Keshavarzi؛ Seyed Rabee Mahdi Mahdavi
Medical Physics Department, School of Medicine, Iran University of Medical Science (IUMS), Thran, Iran
چکیده
Introduction: Currently, the potential application of gold nanoparticles (AuNPs) to increase the efficiency of radiation therapy have been investigated. However, the loss of an appropriate method to estimate the dose distribution in nanoparticle laden tissue limits the applicability of nanoparticles in radiotherapy clinics. Polymer gel dosimetry provides an accurate and precise system that enables to measure the dose distribution in full three dimension. In this study, the radiation dose enhancement effect of AuNPs was assessed through gel dosimetry analysis.
Materials and Methods: To achieve the mentioned goal, AuNPs were impegrated in MAGIC_f polymer gel dosimeter and irradiated by 6Mv X-ray beam. Irradiated gel was then evaluated by two modalities of Magnetic Resonance Imaging (MRI) and Optical Computed Tomography (OCT).
Results: MRI and OCT scanning of the MAGIC_f geles containing 0.1 mM AuNPs demonstrated dose enhancements of 7.8% and 6.8%, respectively.
Conclusion: Polymer gel dosimetry has the potential to provide a new platform for investigation and optimization of the applicability of nanoparticles in radiation therapy
کلیدواژه‌ها
Radiation therapy؛ Gold nanoparticles؛ polymer gel dosimetry؛ Optical computed tomography
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