Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 10، دوره 22، شماره 4، تیر 2019، صفحه 407-411 اصل مقاله (562.3 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2019.33493.7996 | ||
| نویسندگان | ||
| Evren Kose* 1؛ Fatih Oguz2؛ Nigar Vardi3؛ Mehmet Sarihan4؛ Ali Beytur2؛ Aytac yucel5؛ Alaadin Polat6؛ Nihat Ekinci7 | ||
| 1Department of Anatomy, School of Medicine, Inonu University, Malatya, Turkey | ||
| 2Department of Urology, School of Medicine, Inonu University, Malatya, Turkey | ||
| 3Department of Histology-Embryology, School of Medicine, Inonu University, Malatya, Turkey | ||
| 4Department of Emergency, School of Medicine, Inonu University, Malatya, Turkey | ||
| 5Department of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey | ||
| 6Department of Physiology, School of Medicine, Inonu University, Malatya, Turkey | ||
| 7Department of Anatomy, School of Medicine, Erciyes University, Kayseri, Turkey | ||
| چکیده | ||
| Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats. Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically. Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group. On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues. | ||
| کلیدواژهها | ||
| Doxorubicin؛ Histology؛ Kidney؛ Leukotrienes؛ Oxidative stress؛ TBARS | ||
| مراجع | ||
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