The effect of alpha linolenic acid on tracheal responsiveness, lung inflammation and immune markers in sensitized rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 6، دوره 22، شماره 3، خرداد 2019، صفحه 255-261 اصل مقاله (637.26 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2019.27381.6684 | ||
| نویسندگان | ||
| Mahsa Kaveh1؛ Naeima Eftekhar2؛ Mohammad Hossein Boskabady* 3، 4 | ||
| 1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Iran | ||
| 3Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): The effects of alpha linolenic acid (ALA) on tracheal responsiveness (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), interleukin 4 (IL-4), interferon gamma (INF-γ) level and INF-γ/IL4 ratio in bronchoalveolar lavage fluid (BALF) of sensitized rats were examined. Materials and Methods: TR to methacholine and ovalbumin (OA), BALF levels of TP, PLA2 and IgE as well as IL-4, INF-γ and INF-γ/IL4 ratio were measured in control group (non-sensitized, group C), sensitized rats to OA (group S), S groups treated with two concentrations of ALA and dexamethasone group. Results: TR to methacholine and OA, BALF levels of TP, PLA2, IgE and IL-4 were significantly increased but BALF level of INF-γ and INF-γ/IL4 ratio decreased in group S compared to group C (PConclusion: Results showed an immune modulatory effect of the ALA that increased INF-γ, INF-γ/IL4 ratio (as an index of Th1/Th2) and decreased IL-4 in sensitized rats. ALA also showed preventive effect on inflammatory markers and tracheal responsiveness in sensitized animals comparable to the effect of dexamethasone. | ||
| کلیدواژهها | ||
| Asthma؛ Alpha linolenic acid؛ Inflammatory markers؛ Sensitized rats؛ Th1/Th2 balance؛ Tracheal responsiveness | ||
| مراجع | ||
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