Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 2، دوره 9، شماره 3، مرداد و شهریور 2019، صفحه 195-212 اصل مقاله (515.95 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2019.12196 | ||
| نویسندگان | ||
| Zahra Gholamnezhad1، 2؛ Farzaneh Shakeri3؛ Saiedeh Saadat4، 5؛ Vahideh Ghorani5، 6؛ Mohammad Hossein Boskabady* 1، 2 | ||
| 1Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 2Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 3Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran | ||
| 4Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 6Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective: Black cumin or Nigella sativa (N. sativa) seed has been widely used traditionally as a medicinal natural product because of its therapeutic effects. In this review, the medicinal properties of N. sativa as a healing remedy for the treatment of respiratory and allergic diseases, were evaluated. Material and Methods: Keywords including Nigella sativa, black seed, thymoquinone, respiratory, pulmonary, lung and allergic diseases were searched in medical and nonmedical databases (i.e. PubMed, Science Direct, Scopus, and Google Scholar). Preclinical studies and clinical trials published between 1993 and 2018 were selected. Results: In experimental and clinical studies, antioxidant, immunomodulatory, anti-inflammatory, antihistaminic, antiallergic, antitussive and bronchodilatory properties of N. sativa different extracts, extracts fractions and constituents were demonstrated. Clinical studies also showed bronchodilatory and preventive properties of the plant in asthmatic patients. The extract of N. sativa showed a preventive effect on lung disorders caused by sulfur mustard exposure. The therapeutic effects of the plant and its constituents on various allergic disorders were also demonstrated. Conclusion: Therefore, N. sativa and its constituents may be considered effective remedies for treatment of allergic and obstructive lung diseases as well as other respiratory diseases. | ||
| کلیدواژهها | ||
| Nigella sativa؛ Thymoquinone؛ Experimental effect؛ Clinical effect؛ Respiratory diseases؛ Allergic diseases | ||
| مراجع | ||
|
Abbas AT, Abdel-Aziz MM, Zalata K, Abd T-DA-G. 2005. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol, 12:95-102.
Abidi A, Robbe A, Kourda N, Ben Khamsa S, Legrand A. 2017. Nigella sativa, a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model. Biomed Pharmacother, 90:626-637.
Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. 2013. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed, 3:337-352.
Ahmad J, Khan RA, Malik MA. 2010. A study of Nigella sativa oil in the management of wheeze associated lower respiratory tract illness in children. Afr J Pharm Pharmacol, 4:436-439.
Al-Jassir MS. 1992. Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia. Food Chem, 45:239-242.
Al-Jawad FH, Al-Razzuqi RA, Hashim HM, Ismael AH. 2012. Broncho-relaxant activity of Nigella sativa versus anthemisnobilis in chronic bronchial asthma; a comparative study of efficacy. IOSR J Pharmac, 2:81-83.
Al-Majed AA, Daba MH, Asiri YA, Al-Shabanah OA, Mostafa AA, El-Kashef HA. 2001. Thymoquinone-induced relaxation of guinea-pig isolated trachea. Res Commun Mol Pathol Pharmacol, 110:333-345.
Al-Sheddi ES, Farshori NN, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA. 2014. Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line. Asian Pac J Cancer Prev, 15:983-987.
Ali BH, Blunden G. 2003. Pharmacological and toxicological properties of Nigella sativa. Phytother Res, 17:299-305.
Alsamarai AM, Abdulsatar M, Ahmed Alobaidi AH. 2014. Evaluation of topical black seed oil in the treatment of allergic rhinitis. Antiinflamm Antiallergy Agents Med Chem, 13:75-82.
Ameen NMA, Altubaigy F, Jahangir T, Mahday IA, Mohammed EA, Musa OAA. 2011. Effect of Nigella sativa and bee honey on pulmonary, hepatic and renal function in Sudanese in Khartoum state. J Med Plant Res, 5:6857-6863.
Ansari MA, Ahmed SP, Haider S, Ansari N. 2006. Nigella sativa: A non-conventional herbal option for the management of seasonal allergic rhinitis. Pak J Pharmacol, 23:31-35.
Ansari MA, Ansari NA, Junejo SA. 2010. Montelukast versus nigella sativa for management of seasonal allergic rhinitis: A single blind comparative clinical trial. Pak J Med Sci, 26:249-254.
Attoub S, Sperandio O, Raza H, Arafat K, Al-Salam S, Al Sultan MA, Al Safi M, Takahashi T, Adem A. 2013. Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo. Fundam Clin Pharmacol, 27:557-569.
Ave-Sina. 1990. Law in medicine (trans: Sharafkhandy A). Ministry of guidance publication, Teheran.
Balaha MF, Tanaka H, Yamashita H, Rahman MNA, Inagaki N. 2012. Oral Nigella sativa oil ameliorates ovalbumin-induced bronchial asthma in mice. Int Immunopharmacol, 14:224-231.
Balkissoon R, Lommatzsch S, Carolan B, Make B. 2011. Chronic obstructive pulmonary disease: a concise review. Med Clin North Am, 95:1125-1141.
Bayir Y, Albayrak A, Can I, Karagoz Y, Cakir A, Suleyman H, Uyanik H, Yayla N, Polat B, Karakus E, Keles MS. 2012. Nigella sativa as a potential therapy for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats. Cell Mol Bio), 58 Suppl:OL1680-1687.
Boskabady H, Keyhanmanesh R, Saadatloo MA. 2008. Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism (s). Indian J Exp Biol, 46:805-810.
Boskabady M, Mohsenpoor N, Takaloo L. 2010. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine, 17:707-713.
Boskabady MH, Javan H, Sajady M, Rakhshandeh H. 2007. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol, 21:559-566.
Boskabady MH, Vahedi N, Amery S, Khakzad MR. 2011. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J Ethnopharmacol, 137:1028-1034.
Büyüköztürk S, Gelincik A, Özşeker F, Genç S, Şavran FO, Kıran B, Yıllar G, Erden S, Aydın F, Çolakoğlu B. 2005. Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice. J Ethnopharmacol, 100:295-298.
Chakravarty N. 1993. Inhibition of histamine release from mast cells by nigellone. Ann Allergy, 70:237-242.
Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D. 2008. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. Int J Clin Pharmacol Ther, 46:295-306.
Ebrahimi H, Fallahi M, Khamaneh AM, Ebrahimi Saadatlou MA, Saadat S, Keyhanmanesh R. 2016. Effect of α‐Hederin on IL‐2 and IL‐17 mRNA and miRNA‐133a Levels in lungs of ovalbumin‐sensitized male rats. Drug Dev Res, 77:87-93.
El-Dakhakhny M, Madi NJ, Lembert N, Ammon HP. 2002. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol, 81:161-164.
El-Khouly D, El-Bakly WM, Awad AS, El-Mesallamy HO, El-Demerdash E. 2012. Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats. Toxicology, 302:106-113.
El Aziz AEA, El Sayed NS, Mahran LG. 2011a. Anti-asthmatic and anti-allergic effects of thymoquinone on airway-induced hypersensitivity in experimental animals. J Applied Pharmaceut Sci, 1:109-117.
El Aziz AEA, El Sayed NS, Mahran LG. 2011b. Anti-asthmatic and anti-allergic effects of thymoquinone on experimentally-induced hypersensitivity. Egypt J Basic Clin Pharmacol, 1:31-41.
El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. 2006a. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int immunopharmacol, 6:1135-1142.
El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC. 2006b. Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta Gen Subj, 1760:1088-1095.
El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. 2006. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett, 106:72-81.
Fallahi M, Keyhanmanesh R, Khamaneh AM, Saadatlou MAE, Saadat S, Ebrahimi H. 2016. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Avicenna J Phytomed, 6:77-85.
Gholamnezhad Z, Boskabady MH, Hosseini M. 2014. Effect of Nigella sativa on immune response in treadmill exercised rat. BMC Complement Altern Med, 14:437.
Gholamnezhad Z, Havakhah S, Boskabady MH. 2016. Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. J Ethnopharmacol, 190:372-386.
Gholamnezhad Z, Keyhanmanesh R, Boskabady MH. 2015a. Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: A review of basic and clinical evidence. J Funct Foods, 17:910-927.
Gholamnezhad Z, Rafatpanah H, Sadeghnia HR, Boskabady MH. 2015b. Immunomodulatory and cytotoxic effects of Nigella sativa and thymoquinone on rat splenocytes. Food Chem Toxicol, 86:72-80.
Gilani A, Aziz N, Khurram I, Chaudhary K, Iqbal A. 2001. Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. J Pak Med Assoc, 51:115-120.
Günel C, Demirci B, Meteoğlu İ, Yılmaz M, Ömürlü İK, Kocatürk T. 2017. The anti-inflammatory effects of thymoquinone in a rat model of allergic rhinitis. J Ear Nose Throat, 27:226-232.
Gunes AE, Gozeneli O, Akal AA, Guldur ME, Savik E. 2017. Reduction of side effects of hyperbaric oxygen therapy with thymoquinone treatment in rats. Undersea Hyperb Med, 44:337-343.
Hossein BM, Nasim V, Sediqa A. 2008. The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed Guinea pigs. Exp Lung Res, 34:183-194.
Hussein El-Tahir KE-D, Bakeet DM. 2006. The black seed Nigella sativa Linnaeus - A mine for multi cures: a plea for urgent clinical evaluation of its volatile oil. J. Taibah Univ Med Sci, 1:1-19.
Işık H, Çevikbaş A, Gürer ÜS, Kıran B, Üresin Y, Rayaman P, Rayaman E, Gürbüz B, Büyüköztürk S. 2010. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract, 19:206-211.
Jafri SH, Glass J, Shi R, Zhang S, Prince M, Kleiner-Hancock H. 2010. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo. J Exp Clin Cancer Res, 29:87.
Kacem R, Meraihi Z. 2006. Effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase activity. Yakugaku Zasshi, 126:301-305.
Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H. 2003. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytothe Res, 17:1209-1214.
Kanter M. 2009. Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations. Acta Histochem, 111:393-403.
Kanter M. 2011. Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats. Toxicol Ind Health, 27:387-395.
Kardani AK, Fitri LE, Barlianto W, Olivianto E, Kusuma C. 2013. The effect of house dust mite immunotherapy, probiotic and Nigella sativa in the number of Th17 cell and asthma control test score. IOSR J Dent Med Sci, 6:37-47.
Keyhanmanesh R, Bagban H, Nazemieh H, Bavil FM, Alipour MR. 2013. The main relaxant constituents of Nigella sativa methanolic fraction on Guinea pig tracheal chains. Iran J Allergy Asthma Immunol, 12:136-143.
Keyhanmanesh R, Gholamnezhad Z, Boskabady MH. 2014a. The relaxant effect of Nigella sativa on smooth muscles, its possible mechanisms and clinical applications. Iran J Basic Med Sci, 17:939-949.
Keyhanmanesh R, Nazemiyeh H, Mazouchian H, Asl MMB, Shoar MK, Alipour MR, Boskabady MH. 2014b. Nigella sativa pretreatment in guinea pigs exposed to cigarette smoke modulates in vitro tracheal responsiveness. Iran Red Crescent Med J, 16: e10421.
Keyhanmanesh R, Pejman L, Omrani H, Mirzamohammadi Z, Shahbazfar AA. 2014c. The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma. BioImpacts, 4:75-81.
Keyhanmanesh R, Saadat S, Mohammadi M, Shahbazfar AA, Fallahi M. 2015. The Protective Effect of α‐Hederin, the Active Constituent of Nigella sativa, on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs. Phytother Res, 29:1761-1767.
Koshak A, Wei L, Koshak E, Wali S, Alamoudi O, Demerdash A, Qutub M, Pushparaj PN, Heinrich M. 2017. Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial. Phytother Res, 31:403-409.
Mansour M, Tornhamre S. 2004. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. J Enzyme Inhib Med Chem, 19:431-436.
Nemmar A, Al-Salam S, Zia S, Marzouqi F, Al-Dhaheri A, Subramaniyan D, Dhanasekaran S, Yasin J, Ali BH, Kazzam EE. 2011. Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone. Br J Pharmacol, 164:1871-1882.
Nickavar B, Mojab F, Javidnia K, Amoli MA. 2003. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch C, 58:629-631.
Nikakhlagh S, Rahim F, Aryani FHN, Syahpoush A, Brougerdnya MG, Saki N. 2011. Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol, 32:402-407.
Norouzi F, Hosseini M, Abareshi A, Beheshti F, Khazaei M, Shafei MN, Soukhtanloo M, Gholamnezhad Z, Anaeigoudari A. 2018. Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment in rats. Drug Chem Toxicol, 28:1-10.
Oysu C, Tosun A, Yilmaz HB, Sahin-Yilmaz A, Korkmaz D, Karaaslan A. 2014. Topical Nigella Sativa for nasal symptoms in elderly. Auris Nasus Larynx, 41:269-272.
Pourgholamhossein F, Sharififar F, Rasooli R, Pourgholi L, Nakhaeipour F, Samareh-Fekri H, Iranpour M, Mandegary A. 2016. Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress. Environ Toxicol Pharmacol, 45:340-345.
Rooney S, Ryan MF. 2005. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res, 25:2199-2204.
Saadat S, Mohammadi M, Fallahi M, Aslani MR. 2015. The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs. J Physiol Sci, 65:285-292.
Saleh S, ElDenshary E, Mahran N. Nigella sativa (Black seed) oil: Anti-inflammatory and antioxidant effects in experimental models of allergic asthma. 19- 20 May 2012, In: First USIM International Conference on Medicine and Health, Kuala Lumpur, Malaysia.
Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, Afzalc MN. 2017. Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial. Ann Saudi Med, 37:64-71.
Shahzad M, Yang X, Asim MR, Sun Q, Han Y, Zhang F, Cao Y, Lu S. 2009. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol, 22:37-43.
Shakeri F, Gholamnezhad Z, Mégarbane B, Rezaee R, Boskabady MH. 2016. Gastrointestinal effects of Nigella sativa and its main constituent, thymoquinone: a review. Avicenna J Phytomed, 6:9-20.
Suddek GM, Ashry NA, Gameil NM. 2013. Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats. Inflammopharmacology, 21:427-435.
Susanti N, Barlianto W, Kalim H, Kusuma HC. 2013. Asthma clinical improvement and reduction in the number of CD4 CD25 foxp3 Treg and CD4 IL-10 cells after administration of immunotherapy house dust mite and adjuvant probiotics and/or Nigella Sativa powder in mild asthmatic children. IOSR J Dent Med Sci, 7:50-59.
Tavakkoli A, Mahdian V, Razavi BM, Hosseinzadeh H. 2017. Review on clinical trials of black seed (Nigella sativa ) and its active constituent, thymoquinone. J Pharmacopuncture, 20:179-193.
Tayman C, Cekmez F, Kafa IM, Canpolat FE, Cetinkaya M, Tonbul A, Uysal S, Tunc T, Sarici SU. 2013. Protective effects of Nigella sativa oil in hyperoxia-induced lung injury. Arch Bronconeumol, 49:15-21.
Tembhurne SV, Feroz S, More BH, Sakarkar DM. 2011. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res, 8:167-177.
Ulasli SS, Celik S, Gunay E, Ozdemir M, Hazman O, Ozyurek A, Koyuncu T, Unlu M. 2013. Anticancer effects of thymoquinone, caffeic acid phenethyl ester and resveratrol on A549 non-small cell lung cancer cells exposed to benzo(a)pyrene. Asian Pac J Cancer Prev, 14:6159-6164.
Wienkotter N, Hopner D, Schutte U, Bauer K, Begrow F, El-Dakhakhny M, Verspohl EJ. 2008. The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. Planta Med, 74:105-108.
Womack K, Anderson M, Tucci M, Hamadain E, Benghuzzi H. 2006. Evaluation of bioflavonoids as potential chemotherapeutic agents. Biomed Sci Instrum, 42:464-469.
Woo CC, Kumar AP, Sethi G, Tan KH. 2012. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol, 83:443-451.
Yang J, Kuang XR, Lv PT, Yan XX. 2015. Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway. Tumour Biol, 36:259-269.
Yoruk O, Tatar A, Keles ON, Cakir A. 2017. The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis. Acta Otorhinolaryngol Ital, 37:32-37.
Zhu N, Zhao X, Xiang Y, Ye S, Huang J, Hu W, Lv L, Zeng C. 2016. Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats. Int J Cardiol, 221:587-596. | ||
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