سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Alboghobeish, Soheila, Mahdavinia, Masoud, Zeidooni, Leila, Samimi, Azin, Oroojan, Ali Akbar, Alizadeh, Saeid, Dehghani, Mohammad Amin, Ahangarpour, Akram, Khorsandi, Layasadat. (1397). Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats. , 22(3), 315-323. doi: 10.22038/ijbms.2019.29757.7184
Soheila Alboghobeish; Masoud Mahdavinia; Leila Zeidooni; Azin Samimi; Ali Akbar Oroojan; Saeid Alizadeh; Mohammad Amin Dehghani; Akram Ahangarpour; Layasadat Khorsandi. "Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats". , 22, 3, 1397, 315-323. doi: 10.22038/ijbms.2019.29757.7184
Alboghobeish, Soheila, Mahdavinia, Masoud, Zeidooni, Leila, Samimi, Azin, Oroojan, Ali Akbar, Alizadeh, Saeid, Dehghani, Mohammad Amin, Ahangarpour, Akram, Khorsandi, Layasadat. (1397). 'Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats', , 22(3), pp. 315-323. doi: 10.22038/ijbms.2019.29757.7184
Alboghobeish, Soheila, Mahdavinia, Masoud, Zeidooni, Leila, Samimi, Azin, Oroojan, Ali Akbar, Alizadeh, Saeid, Dehghani, Mohammad Amin, Ahangarpour, Akram, Khorsandi, Layasadat. Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats. , 1397; 22(3): 315-323. doi: 10.22038/ijbms.2019.29757.7184

Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats

Iranian Journal of Basic Medical Sciences
مقاله 15، دوره 22، شماره 3، خرداد 2019، صفحه 315-323    اصل مقاله (627.53 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.29757.7184
نویسندگان
Soheila Alboghobeish1؛ Masoud Mahdavinia* 2؛ Leila Zeidooni3؛ Azin Samimi3؛ Ali Akbar Oroojan4؛ Saeid Alizadeh3؛ Mohammad Amin Dehghani3؛ Akram Ahangarpour5؛ Layasadat Khorsandi6
1Department of Pharmacology, School of Medicine, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Department of Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran
3Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4Department of Physiology, Student Research Committee of Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
5Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6Department of Histology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.
Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Naringin-administrated (40, 80, 160 mg/kg) and Naringin-treated (160 mg/kg) for 30 days. At the end of experiments, testicular weight, total testicular protein, epididymal sperm count, testicular enzymes, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and estradiol, testicular enzymatic and non-enzymatic antioxidants and histopathology of testis tissue were evaluated by their own methods.  
Results: The results showed a reduction in testicular weight, total testicular protein, epididymal sperm count, testicular enzymes (alkaline phosphatase and lactate dehydrogenase) and decrease in the serum TSH, LH, testosterone and estradiol in BPA-administrated rats. Furthermore, BPA reduced the enzyme activities of glutathione peroxidase, superoxide dismutase, and catalase in testis tissue. Also, BPA caused an induction in lipid peroxidation and increase in reactive oxygen species levels, whereas it decreased the glutathione content of testis tissue. Histological findings exhibited seminiferous tubules vacuoles, atrophy and separation of the germinal epithelium in BPA-administrated rats. Oral administration of Naringin along with BPA normalized the biochemical, morphological and histological changes and reduced the testicular toxic condition.
Conclusion: These results demonstrated that Naringin significantly managed male reproductive toxicity by antioxidant capabilities, preventing morphological modifications and escalating defense mechanism, thereby reducing oxidative stress from BPA-induced damage.
کلیدواژه‌ها
Bisphenol A؛ Endocrine-disrupting chemicals؛ Naringin؛ Oxidative stress؛ Testicular toxicity
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