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Boroushaki, Mohammad Taher, Fanoudi, Sahar, Mollazadeh, Hamid, Boroumand-Noughabi, Samaneh, Hosseini, Azar. (1397). Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity. , 22(3), 328-333. doi: 10.22038/ijbms.2019.31552.7597
Mohammad Taher Boroushaki; Sahar Fanoudi; Hamid Mollazadeh; Samaneh Boroumand-Noughabi; Azar Hosseini. "Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity". , 22, 3, 1397, 328-333. doi: 10.22038/ijbms.2019.31552.7597
Boroushaki, Mohammad Taher, Fanoudi, Sahar, Mollazadeh, Hamid, Boroumand-Noughabi, Samaneh, Hosseini, Azar. (1397). 'Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity', , 22(3), pp. 328-333. doi: 10.22038/ijbms.2019.31552.7597
Boroushaki, Mohammad Taher, Fanoudi, Sahar, Mollazadeh, Hamid, Boroumand-Noughabi, Samaneh, Hosseini, Azar. Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity. , 1397; 22(3): 328-333. doi: 10.22038/ijbms.2019.31552.7597

Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity

Iranian Journal of Basic Medical Sciences
مقاله 17، دوره 22، شماره 3، خرداد 2019، صفحه 328-333    اصل مقاله (512.04 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22038/ijbms.2019.31552.7597
نویسندگان
Mohammad Taher Boroushaki1؛ Sahar Fanoudi1؛ Hamid Mollazadeh2؛ Samaneh Boroumand-Noughabi3، 4؛ Azar Hosseini* 5
1Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Deparment of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract of Rheum turkestanicum was used against gentamicin- induced nephrotoxicity. Rheum turkestanicum is used against gentamicin-induced nephrotoxicity and in this study its effect against gentamicin-induced nephrotoxicity in rats has been investigated.
Materials and Methods: The rats were placed into one of these groups: saline group, gentamicin group that received gentamicin 80 mg/kg/day for six days, and two treatment groups that received R. turkestanicum intraperitoneally at doses of 100 and 200 mg/kg body weight, respectively, 1 hr before gentamicin injections. Urine samples were collected at 24 hr to measure glucose and protein concentration. Blood samples were collected to determine serum urea and creatinine. One kidney was homogenized to measure malondialdehyde and thiol, and the other kidney was kept for pathological studies.
Results: Gentamicin increased the level of urinary glucose and protein, and increased malondialdehyde while it decreased thiol in kidney tissue, and increased the concentration of urea and creatinine in the serum. Histopathological pathology revealed renal damage following gentamicin usage; however, the extract was able to improve gentamicin toxicity.
Conclusion: R. turkestanicum has positive effects in the attenuation of gentamicin-induced nephrotoxicity.
کلیدواژه‌ها
Rheum turkestanicum؛ Gentamicin؛ Reactive oxygen species؛ Malondialdehyde؛ Oxidative stress
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