Improving the mechanical and bioactivity of hydroxyapatite porous scaffold ceramic with diopside/forstrite ceramic coating | ||
| Nanomedicine Journal | ||
| مقاله 7، دوره 6، شماره 1، فروردین 2019، صفحه 50-54 اصل مقاله (825.31 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22038/nmj.2019.05.007 | ||
| نویسندگان | ||
| Sorour Sadeghzade* ؛ Rahmatollah Emadi | ||
| Materials Research Group, Department of Materials engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran | ||
| چکیده | ||
| Objective(s): Scaffolds are considered as biological substitutes in bone defects which improve and accelerate the healing process of surrounding tissue. In recent years a major challenge in biomaterials is to produce porous materials with properties similar to bone tissue. In this study, the natural bioactive hydroxyapatite scaffolds with nano Diopside /Forstrite coating was successfully synthesized to be used in tissue engineering applications. Materials and Methods: The spongy part of bovine bone was cut and the subsequent sintering temperature was applied for fabrication of natural hydroxyapatite. Then the scaffolds were coated with 30 wt% nano-Diopside/Forstrite composite slurry. The scaffolds were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy-dispersive spectroscope (EDS). Results: In the present study, the mechanical properties of natural HA scaffold were improved when coated with a composite nmaed Diopside/Forstrite ceramic. The optimum properties were evaluated for the scaffolds containing 30 wt% composite ceramic coating. The pore size of the obtained scaffold was measured to be in the range of 300-400 nm. Compressive strength and porosity of the composite scaffold were approximately 1.5±0.2 MPa and 93±1.1 MPa, respectively. Conclusions: Based on the mechanical and bioactivity result, the natural bioactive hydroxyapatite scaffolds with nano Diopside /Forstrite coating showed improved mechanical properties, pore size, porosity content and apatite formation ability whcih can be a promising candidate for bone tissue engineering applications. | ||
| کلیدواژهها | ||
| Porous materials؛ Hydroxyapatite؛ Coating؛ Forstrite؛ Diopside | ||
| مراجع | ||
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1.Gerhardt LC, Boccaccini AR. Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials. 2010; 3: 3867-3910. 2.Bellucci D, Cannillo V, Sola A, Chiellini F, Gazzarri M, Migone C. Macroporous Bioglass-derived scaffolds for bone tissue regeneration. Ceram Int. 2011; 37: 1575-1585. 3.Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng. 2001; 7; 679−689. 4.Sadeghzade S, Emadi R, Tavangarian F. Combustion assisted synthesis of hardystonite nanopowder. Ceram Int. 2016; 42; 14656-14660. 5.Conrad HJ, Seong WJ, Pesun GJ. Current ceramic materials and systems with clinical recommendations: a systematic review, J. Prosthet Dent. 2007; 98: 389-404. 6.Diba M, Goudouri O M, Tapia F, Boccaccini AR. Magnesium- containing bioactive polycrystalline silicate- based ceramics and glass- ceramics for biomedical. Curr. Opin. Solid State Mater Sci. 2014; 18: 147-168. 7. Sadeghzade S, Emadi R, Labbaf S. Formation mechanism of nano-hardystonite powder prepared by mechanochemical synthesis, Adv Powder Techno. 2016; 27: 2238-2244. 8. Ramaswamy Y, Wu C, Zhou H, Zreiqat H, Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomater. 2008; 4: 1487-1497. 9. Ghomi H, Jaberzadeh M, Fathi M H, Novel fabrication of forsterite scaffold with improved mechanical properties. J alloy Compd. 2011; 509: 63-68. 11.Tavangarian F, Emadi R. Nanostructure effects on the bioactivity of forsterite bioceramic. Mater Lett. 2011; 65: 740-743. 12.Roohani-Esfahani SI, Chen Y, Shi J, Zreiqat H. Fabrication and characterization of a new, strong and bioactive ceramic scaffold for bone regeneration. Mater Lett. 2013; 107: 378-381. 13.Sadeghzade S, Emadi R, Tavangarian F, Naderi M. Fabrication and evaluation of silica-based ceramic scaffolds for hard tissue engineering applications. Mater. Sci Eng C. 2017; 71: 431-438 14.Pangon A, Saesoo S, Saengkrit N, Ruktanonchai U, Intasanta V. Hydroxyapatite-hybridized chitosan/chitin whisker bionanocomposite fibers for bone tissue engineering applications. Carbohydr. polym. 2016; 144: 419-427. 15.Tadic D, Beckmann F, Schwarz K, Epple M. A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering. Biomaterials. 2004; 25: 3335-3340. 16.Gerhardt LC, Boccaccini AR. Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials. 2010; 3: 3867-3910. 17.Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng. 2001; 7: 679-689. 18.Nagels J, Stokdijk M, Rozing PM. Stress shielding and bone resorption in shoulder arthroplasty. J Should Elbow Surg. 2003; 12: 35-39. 19.Sadeghzade S, Emadi R, Soleimani B, Tavangarian F. Two-step modification process to improve mechanical properties and bioactivity of hydroxyfluorapatite scaffolds. Ceram Int. 2018; 44: 19756-19763. 20.Porter AE, Patel N, Skepper JN, Best SM, Bonfield W. Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics. Biomaterials. 2003; 24: 4609-4620. 21.Sadeghzade S, Emadi R, Ghomi H. Mechanical alloying synthesis of forsterite-diopside nanocomposite powder for using in tissue engineering. Ceramics–Silikáty. 2015; 59: 1-5. 22.Sadeghzade S, Shamoradi F, Emadi R, Tavangarian F. Fabrication and characterization of baghdadite nanostructured scaffolds by space holder method. J. Mecha. Behave Biomed Mater. 2017; 68: 1-7. 23.Sadeghzade S, Emadi R, Labbaf S. Hardystonite-diopside nanocomposite scaffolds for bone tissue engineering applications. Mater Chem Phy. 2017; 202: 95-103. | ||
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