سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

pourhabib, zahra, Ranjbar, Hassan, Bahrami Samani, Ali, Shokri, AliAsghar. (1398). Optimization of Natural Rhenium Irradiation Time to Produce Compositional Radiopharmaceutical. , 16(5), 362-367. doi: 10.22038/ijmp.2018.33853.1421
zahra pourhabib; Hassan Ranjbar; Ali Bahrami Samani; AliAsghar Shokri. "Optimization of Natural Rhenium Irradiation Time to Produce Compositional Radiopharmaceutical". , 16, 5, 1398, 362-367. doi: 10.22038/ijmp.2018.33853.1421
pourhabib, zahra, Ranjbar, Hassan, Bahrami Samani, Ali, Shokri, AliAsghar. (1398). 'Optimization of Natural Rhenium Irradiation Time to Produce Compositional Radiopharmaceutical', , 16(5), pp. 362-367. doi: 10.22038/ijmp.2018.33853.1421
pourhabib, zahra, Ranjbar, Hassan, Bahrami Samani, Ali, Shokri, AliAsghar. Optimization of Natural Rhenium Irradiation Time to Produce Compositional Radiopharmaceutical. , 1398; 16(5): 362-367. doi: 10.22038/ijmp.2018.33853.1421

Optimization of Natural Rhenium Irradiation Time to Produce Compositional Radiopharmaceutical

Iranian Journal of Medical Physics
مقاله 8، دوره 16، شماره 5، آذر و دی 2019، صفحه 362-367    اصل مقاله (889.55 K)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.33853.1421
نویسندگان
zahra pourhabib1؛ Hassan Ranjbar* 2؛ Ali Bahrami Samani2؛ AliAsghar Shokri1
1Department of Physics, Payame Noor University (PNU), Tehran, Iran.
2Material and Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran.
چکیده
Introduction: Previously, 186Re and 188Re radioisotopes have been produced through appropriate activities, and each of them has been used for therapeutic applications. The 186Re and 188Re have unique properties, which make them proper for the treatment of  tumors in different sizes. The long-range 188Re, is suitable for the annihilation of large tumors. In contrast, the short-range 186Re is desirable for the destruction of small tumors. The aim of this study was to find the suitable time for rhenium irradiation in order to simultaneously produce radionuclides with both appropriate and identical activities.
Material and Methods: To reach 186Re and 188Re with appropriate activities to produce compositional radiopharmaceutical, we have investigated natural rhenium irradiation at different times to produce 186Re and 188Re simultaneously with appropriate and identical activities to reach compositional radiopharmaceutical. In this regard, the simultaneous production of 186Re and 188Re with appropriate activities were investigated analytically through natural rhenium irradiation in a reactor. The irradiation was assessed at different time intervals in order to reach appropriate activities for compositional radiopharmaceuticals.
Results: On the basis of the findings, 186Re and 188Re could be produced simultaneously with suitable and almost equal activities with irradiating natural rhenium for 4 days and considering 1 day for cooling. Moreover, the obtained results of this study revealed that the generated impurities were negligible.
Conclusion: The optimization of natural rhenium irradiation time can help the simultaneous production of 186Re and 188Re with appropriate activities for compositional radiopharmaceuticals. 
کلیدواژه‌ها
Radioisotope؛ Radiopharmaceutical؛ Rhenium-186؛ Rhenium-188
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