Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 1، دوره 22، شماره 2، اردیبهشت 2019، صفحه 112-117 اصل مقاله (743.99 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2018.30825.7436 | ||
| نویسندگان | ||
| Wei-wei Wang1؛ Xiao-lei Liu2؛ Ye Ruan3؛ Lin Wang1؛ Tianhao Bao* 1، 3 | ||
| 1The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China | ||
| 2The First Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China | ||
| 3Mental Health Center of Kunming Medical University, Kunming City, Yunnan Province, PR China | ||
| چکیده | ||
| Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment and implementation of inclusion/exclusion criteria. This meta-analysis was performed using Review Manager 5.2 software. The odds ratios (ORs) with corresponding 95% confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger’s regression tests were used to assess the publication bias. Results: A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE polymorphisms and depression. APOE ε4 allele was significantly associated with depression (allele: OR=1.36, 95%CI=1.11-1.66, P=0.003; dominant: OR=1.34, 95%CI=1.06-1.68, P=0.001; recessive: OR= 1.11, 95%CI =0.45-2.76, P=0.82). HAMD scores were higher in depression patients with-APOE ε4 genotype than who without-APOE ε4 genotype (OR=0.96, 95%CI=0.16-1.76, P=0.02). Conclusion: APOE ε4 allele increased the depression risk; depressive patients carrying APOE ε4 allele had more severe depressive symptoms. | ||
| کلیدواژهها | ||
| Apolipoprotein E؛ Depression؛ Meta-analysis؛ Polymorphism؛ ε4 allele | ||
| مراجع | ||
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