سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

قاسمی, داوذ, سنکیان, مجتبی, فرخی فرد, عارف. (1397). آپتامرهای نوکلئیک اسیدی: ابزارهای نوین در تشخیص و درمان. , 7(4), 99-113. doi: 10.22038/jpsr.2018.24337.1647
داوذ قاسمی; مجتبی سنکیان; عارف فرخی فرد. "آپتامرهای نوکلئیک اسیدی: ابزارهای نوین در تشخیص و درمان". , 7, 4, 1397, 99-113. doi: 10.22038/jpsr.2018.24337.1647
قاسمی, داوذ, سنکیان, مجتبی, فرخی فرد, عارف. (1397). 'آپتامرهای نوکلئیک اسیدی: ابزارهای نوین در تشخیص و درمان', , 7(4), pp. 99-113. doi: 10.22038/jpsr.2018.24337.1647
قاسمی, داوذ, سنکیان, مجتبی, فرخی فرد, عارف. آپتامرهای نوکلئیک اسیدی: ابزارهای نوین در تشخیص و درمان. , 1397; 7(4): 99-113. doi: 10.22038/jpsr.2018.24337.1647

آپتامرهای نوکلئیک اسیدی: ابزارهای نوین در تشخیص و درمان

فصلنامه علمی- پژوهشی علوم پیراپزشکی وتوانبخشی
مقاله 10، دوره 7، شماره 4، دی 1397، صفحه 99-113    اصل مقاله (919.91 K)
نوع مقاله: مقاله مروری
شناسه دیجیتال (DOI): 10.22038/jpsr.2018.24337.1647
نویسندگان
داوذ قاسمی1؛ مجتبی سنکیان* 2؛ عارف فرخی فرد3
1دانشجوی کارشناسی ارشدگروه ایمونولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
2دانشیار گروه ایمونولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
3دانشجوی دکتری تخصصی گروه بیوتکنولوژی، انستیتو پاستور ایران، تهران، ایران
چکیده
چکیده
آپتامرها توالی ­های کوتاه تک رشته ­ای اسید نوکلئیکی (DNA یا RNA) یا پپتیدی با ساختار سه بعدی ویژه­ای هستند که قادرند با اختصاصیت و تمایل بالایی به اهداف خود متصل شوند. اندازه کوچک، فرایند تولید سریع و ارزان، ایمنی ­زایی اندک و پایداری بالا، آن ها را به مولکول­ های جذابی در برخی زمینه­های پژوهشی به ویژه در طراحی مسیر­های تشخیصی و درمانی جدید تبدیل کرده است. در این مقاله مروری، فرآیند تولید آپتامر­های اسید نوکلئیکی، مزایا و معایب آن ها در مقایسه با آنتی­ بادی ­ها و پتانسیل­ های کاربردیشان در پزشکی بحث می ­شود. همچنین محدودیت های آپتامرها و راه­کارهای غلبه بر آن نیز مورد بررسی قرار می­ گیرد.
کلیدواژه‌ها
آپتامر نوکلئیک اسیدی؛ آنتی بادی؛ Pegaptanib
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