سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nikmahzar, Emsehgol, Jahanshahi, Mehrdad, Elyasi, Leila, Saeidi, Mohsen, Babakordi, Fatemeh, Bahlakeh, Gozal. (1397). Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density. , 22(2), 166-172. doi: 10.22038/ijbms.2018.31412.7569
Emsehgol Nikmahzar; Mehrdad Jahanshahi; Leila Elyasi; Mohsen Saeidi; Fatemeh Babakordi; Gozal Bahlakeh. "Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density". , 22, 2, 1397, 166-172. doi: 10.22038/ijbms.2018.31412.7569
Nikmahzar, Emsehgol, Jahanshahi, Mehrdad, Elyasi, Leila, Saeidi, Mohsen, Babakordi, Fatemeh, Bahlakeh, Gozal. (1397). 'Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density', , 22(2), pp. 166-172. doi: 10.22038/ijbms.2018.31412.7569
Nikmahzar, Emsehgol, Jahanshahi, Mehrdad, Elyasi, Leila, Saeidi, Mohsen, Babakordi, Fatemeh, Bahlakeh, Gozal. Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density. , 1397; 22(2): 166-172. doi: 10.22038/ijbms.2018.31412.7569

Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density

Iranian Journal of Basic Medical Sciences
مقاله 9، دوره 22، شماره 2، اردیبهشت 2019، صفحه 166-172    اصل مقاله (937.54 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.31412.7569
نویسندگان
Emsehgol Nikmahzar1؛ Mehrdad Jahanshahi* 2؛ Leila Elyasi2؛ Mohsen Saeidi3؛ Fatemeh Babakordi1؛ Gozal Bahlakeh1
1Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3Stem Cell Research Center, Department of Immunology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
چکیده
Objective(s): Amyloid β plaques, in Alzheimer’s disease, are deposits in different areas of the brain such as prefrontal cortex, molecular layer of the cerebellum, and the hippocampal formation. Amyloid β aggregates lead to the release of cytochrome c and finally neuronal cell death in brain tissue. hCG has critical roles in brain development, neuron differentiation, and function. Therefore, we investigated the effect of hCG on the density of the congophilic Aβ plaque and cytochrome c-ir neurons in the hippocampus, prefrontal cortex, and cerebellum of Streptozotocin (STZ)-treated rats.
Materials and Methods: Alzheimer model in rats (except the control group) was induced by streptozotocin (3 mg/kg, Intracerebroventricularly (ICV)). Experimental group rats received streptozotocin and then different doses of hCG (50, 100, and 200 IU, intraperitoneally) for 3 days. 48 hr after last drug injection and after histological processing, the brain sections were stained by congo red for congophilic amyloid β plaques and cytochrome c in the hippocampus, prefrontal cortex, and cerebellum were immunohistochemically stained.
Results: Density of congophilic Aβ plaques and cytochrome c-immunoreactive neurons was significantly higher in ICV STZ treated rats than controls. Treatment with three doses of hCG significantly decreased the density of congophilic Aβ plaques and cytochrome c-immunoreactive neurons in the rat hippocampus, prefrontal cortex, and cerebellum in ICV STZ-treated rats (P<0.05).
Conclusion: hCG can be useful in AD patients to prevent the congophilic Aβ plaque formation and decrease cytochrome c-immunoreactive neuron density in the brain.
کلیدواژه‌ها
Amyloid plaque؛ Brain؛ Cytochrome c؛ Human chorionic gonadotropin؛ Rat؛ Streptozotocin
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