سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Zavvari Oskuye, Zohreh, Mirzaie Bavil, Fariba, Hamidian, Gholamreza, Mehri, Keivan, Qadiri, Afsaneh, Ahmadi, Mahdi, Ogbaei, Hajar, Vatankhah, Amir Mansour, Keyhanmanesh, Rana. (1397). Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats. , 22(2), 197-205. doi: 10.22038/ijbms.2018.32678.7814
Zohreh Zavvari Oskuye; Fariba Mirzaie Bavil; Gholamreza Hamidian; Keivan Mehri; Afsaneh Qadiri; Mahdi Ahmadi; Hajar Ogbaei; Amir Mansour Vatankhah; Rana Keyhanmanesh. "Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats". , 22, 2, 1397, 197-205. doi: 10.22038/ijbms.2018.32678.7814
Zavvari Oskuye, Zohreh, Mirzaie Bavil, Fariba, Hamidian, Gholamreza, Mehri, Keivan, Qadiri, Afsaneh, Ahmadi, Mahdi, Ogbaei, Hajar, Vatankhah, Amir Mansour, Keyhanmanesh, Rana. (1397). 'Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats', , 22(2), pp. 197-205. doi: 10.22038/ijbms.2018.32678.7814
Zavvari Oskuye, Zohreh, Mirzaie Bavil, Fariba, Hamidian, Gholamreza, Mehri, Keivan, Qadiri, Afsaneh, Ahmadi, Mahdi, Ogbaei, Hajar, Vatankhah, Amir Mansour, Keyhanmanesh, Rana. Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats. , 1397; 22(2): 197-205. doi: 10.22038/ijbms.2018.32678.7814

Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 22، شماره 2، اردیبهشت 2019، صفحه 197-205    اصل مقاله (904.51 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.32678.7814
نویسندگان
Zohreh Zavvari Oskuye1؛ Fariba Mirzaie Bavil2؛ Gholamreza Hamidian3؛ Keivan Mehri1؛ Afsaneh Qadiri4؛ Mahdi Ahmadi5؛ Hajar Ogbaei4؛ Amir Mansour Vatankhah2؛ Rana Keyhanmanesh* 2
1Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
4Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Objective(s): Diabetes can gradually cause damage to the function and structure of male gonads. This survey was conducted to investigate the effect of troxerutin on hormonal changes, serum oxidative stress indices, and testicular function and structure in prepubertal diabetic rats.
Materials and Methods: Fifty prepubertal (6 weeks old) male Wistar rats were divided into five groups including Control, Troxerutin, Diabetic, Diabetic+Troxerutin, and Diabetic+Insulin. Type I diabetes was induced by 55 mg/kg of streptozotocin intraperitoneally. The groups were treated with 150 mg/kg/day troxerutin via oral gavage or 4-6 IU/day insulin via subcutaneous injection for 4 consecutive weeks. Blood sugar (BS) and serum levels of insulin, FSH, LH, testosterone, glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA), and total antioxidant capacity (TAC) were analyzed. Testis and epididymis were removed for histopathologic study and analysis of sperm parameters.
Results: Troxerutin significantly reduced the BS in the diabetic group similar to insulin but could not affect insulin, FSH, or LH significantly. Troxerutin caused a significant increase in testosterone and GPX but had no significant effect on serum MDA, TAC, and SOD levels. In addition, troxerutin had a better effect than insulin on diabetes-induced testicular structural damage. Sperm analysis results also revealed that troxerutin and insulin could improve sperm number, motility, and viability in diabetic rats.
Conclusion: According to these results, it can be derived that administration of troxerutin is a suitable protective strategy for side effects of diabetes in testis of prepubertal diabetic male rats.
کلیدواژه‌ها
Diabetes؛ FSH؛ LH؛ Oxidative stress؛ Prepubertal؛ Troxerutin
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