سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Wang, Shi-Biao, Guo, Xiao-Feng, Weng, Bin, Tang, Su-Ping, Zhang, Hui-Jie. (1397). Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma. , 22(2), 160-165. doi: 10.22038/ijbms.2018.30598.7375
Shi-Biao Wang; Xiao-Feng Guo; Bin Weng; Su-Ping Tang; Hui-Jie Zhang. "Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma". , 22, 2, 1397, 160-165. doi: 10.22038/ijbms.2018.30598.7375
Wang, Shi-Biao, Guo, Xiao-Feng, Weng, Bin, Tang, Su-Ping, Zhang, Hui-Jie. (1397). 'Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma', , 22(2), pp. 160-165. doi: 10.22038/ijbms.2018.30598.7375
Wang, Shi-Biao, Guo, Xiao-Feng, Weng, Bin, Tang, Su-Ping, Zhang, Hui-Jie. Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma. , 1397; 22(2): 160-165. doi: 10.22038/ijbms.2018.30598.7375

Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma

Iranian Journal of Basic Medical Sciences
مقاله 8، دوره 22، شماره 2، اردیبهشت 2019، صفحه 160-165    اصل مقاله (540.35 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.30598.7375
نویسندگان
Shi-Biao Wang1؛ Xiao-Feng Guo* 1؛ Bin Weng1؛ Su-Ping Tang2؛ Hui-Jie Zhang1
1Department of Pediatric, Fujian Provincial Meternity and Children’s Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
2Department of Allergy, Fuzhou Children’s Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China
چکیده
Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA).
Materials and Methods: Male BALB/c mice were used in the present study. The mice were sensitized by OVA intraperitoneal injection on days 0 and 14, and received aerosolized OVA challenge for 30 min daily on days 21-23Results: T. T. IIA (10 mg/kg twice daily) intraperitoneal injection was performed on days 18-23.
Results: Treatment of T. IIA reduced the levels of interleukin (IL)-4, IL-5, and IL-13 in bronchoalveolar lavage fluid (BALF) (PConclusion: T. IIA inhibits OVA-induced airway inflammation and hyperresponsiveness. T. IIA is a potential therapeutic agent for asthma.
کلیدواژه‌ها
Asthma؛ Inflammation؛ Nuclear factor-κB؛ Oxidative stress؛ Tanshinone IIA
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