سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Al-lawama, Manar, Almustafa, Asma, Elrimawi, Ala, Bani Mustafa, Amal, Almomani, Suzan, Badran, Eman. (1397). Varicella Exposure in Neonatal Intensive Care Unit in a Low Resource Country: Successful Prophylaxis with Intravenous Immunoglobulins. , 10(1), 31-34. doi: 10.22038/ijn.2018.34426.1502
Manar Al-lawama; Asma Almustafa; Ala Elrimawi; Amal Bani Mustafa; Suzan Almomani; Eman Badran. "Varicella Exposure in Neonatal Intensive Care Unit in a Low Resource Country: Successful Prophylaxis with Intravenous Immunoglobulins". , 10, 1, 1397, 31-34. doi: 10.22038/ijn.2018.34426.1502
Al-lawama, Manar, Almustafa, Asma, Elrimawi, Ala, Bani Mustafa, Amal, Almomani, Suzan, Badran, Eman. (1397). 'Varicella Exposure in Neonatal Intensive Care Unit in a Low Resource Country: Successful Prophylaxis with Intravenous Immunoglobulins', , 10(1), pp. 31-34. doi: 10.22038/ijn.2018.34426.1502
Al-lawama, Manar, Almustafa, Asma, Elrimawi, Ala, Bani Mustafa, Amal, Almomani, Suzan, Badran, Eman. Varicella Exposure in Neonatal Intensive Care Unit in a Low Resource Country: Successful Prophylaxis with Intravenous Immunoglobulins. , 1397; 10(1): 31-34. doi: 10.22038/ijn.2018.34426.1502

Varicella Exposure in Neonatal Intensive Care Unit in a Low Resource Country: Successful Prophylaxis with Intravenous Immunoglobulins

Iranian Journal of Neonatology
مقاله 5، دوره 10، شماره 1، خرداد 2019، صفحه 31-34    اصل مقاله (289.13 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijn.2018.34426.1502
نویسندگان
Manar Al-lawama* 1؛ Asma Almustafa2؛ Ala Elrimawi2؛ Amal Bani Mustafa2؛ Suzan Almomani2؛ Eman Badran2
1Consultant, Neonatal-Perinatal Medicine, University of Jordan
2University of Jordan
چکیده
Background: Varicella-zoster infection is a serious and potentially fatal disease, especially among newborns.Several studies have described postnatal varicella zoster exposure among neonates and reported on the efficacy of varicella-zoster immunoglobulins (VZIG) used as post-exposure prophylaxis. Unfortunately, VZIG is not available in Jordan. A limited number of studies have investigated the efficacy of intravenous immunoglobulins (IVIG) as an alternative preventive post-exposure to the varicella virus.
Methods: This retrospective descriptive study was conducted to review the outcomes of two separate incidents of varicella-zoster exposure and the prophylactic use of IVIG in the neonatal intensive care unit in Jordan.
Results: The sources of exposure in both incidents infected medical health workers. During the exposure, cohort measures were applied to neonates whose mothers did not receive immune prophylaxis against IVIG. Newborns were followed appropriately. Totally, 22 cases were identified representing two exposure incidents without a varicella-zoster infection.
Conclusion: The results indicated that IVIG was an effective prophylactic therapy for neonates post varicella virus exposure.
کلیدواژه‌ها
Intravenous immunoglobulin؛ Neonate؛ Postnatal exposure؛ Prophylaxis؛ Varicella-zoster
مراجع

1. Yu HR, Huang YC, Yang KD. Neonatal varicella frequently associated with visceral complications: a retrospective analysis. Acta Paediatr Taiwan. 2003; 44(1):25-8.

2. Gustafson TL, Shehab Z, Brunell PA. Outbreak of varicella in a newborn intensive care nursery. Am J Dis Child. 1984; 138(6):548-50.

3. Ng PC, Lyon DJ, Wong MY, Fok TF, Wong W, Cheung KL, et al. Varicella exposure in a neonatal intensive care unit: emergency management and control measures. J Hosp Infect. 1996; 32(3):229-36.

4. Gold WL, Boulton JE, Goldman C, Gershon A, Steinberg SP, Chua R, et al. Management of varicella exposures in the neonatal intensive care unit. Pediatr Infect Dis J. 1993; 12(11):954-5.

5. Lipton SV, Brunell PA. Management of varicella exposure in a neonatal intensive care unit. JAMA. 1989; 261(12):1782-4.

6. Stover BH, Cost KM, Hamm C, Adams G, Cook LN. Varicella exposure in a neonatal intensive care unit: case report and control measures. Am J Infect Control. 1988; 16(4):167-72.

7. Centers for Disease Control and Prevention (CDC). FDA approval of an extended period for administering VariZIG for postexposure prophylaxis of varicella. MMWR Morb Mortal Wkly Rep. 2012; 61(12):212.

8. Patou G, Midgley P, Meurisse EV, Feldman RG. Immunoglobulin prophylaxis for infants exposed to varicella in a neonatal unit. J Infect. 1990; 20(3):207-13.

9. American American Academy of Pediatrics. Varicella-zoster virus infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, editors. Red Book®: 2015 report of the committee on infectious diseases. New York: American Academy of Pediatrics; 2015. P. 846-60.

 10. Ogilvie MM. Antiviral prophylaxis and treatment in chickenpox. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. J Infect. 1998; 36(Suppl 1):31-8.

11. Heuchan AM, Isaacs D. The management of varicella-zoster virus exposure and infection in pregnancy and the newborn period. Australasian Subgroup in Paediatric Infectious Diseases of the Australasian Society for Infectious Diseases. Med J Aust. 2001; 174(6):288-92.

 12. Hayakawa M, Kimura H, Ohshiro M, Kato Y, Fukami E, Yasuda A, et al. Varicella exposure in a neonatal medical centre: successful prophylaxis with oral acyclovir. J Hosp Infect. 2003; 54(3):212-5.

13. Kellie SM, Makvandi M, Muller ML. Management and outcome of a varicella exposure in a neonatal intensive care unit: lessons for the vaccine era. Am J Infect Control. 2011; 39(10):844-8.

آمار
تعداد مشاهده مقاله: 596
تعداد دریافت فایل اصل مقاله: 587