Evaluation of the use of gold nanoparticle as contrast agent in electrical impedance imaging | ||
| Iranian Journal of Medical Physics | ||
| مقاله 53، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 53-53 | ||
| نوع مقاله: Conference Proceedings | ||
| شناسه دیجیتال (DOI): 10.22038/ijmp.2018.11954 | ||
| نویسندگان | ||
| Mohsen Ostovari1؛ Nader Riahi Alam2؛ Mohammad Momen Gharibvand3؛ Mojtaba Hoseini4؛ mansour zabihzadeh* 5 | ||
| 1Assistant Professor, Department of Medical Physics and Biomedical Engineering, Shiraz University of Medical Physics, Shiraz, Iran. | ||
| 2Professor, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Physics, Tehran, Iran. | ||
| 3M.D. Assistant Professor, Department of Radiology, school of medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 4PhD student, Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| 5Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Radiotherapy and Radiation Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. | ||
| چکیده | ||
| Introduction: Electrical Impedance Tomography (EIT) is a real time and minimal invasive imaging modality for detection of lesions in tissues even when their structures show no changes. Early detection of lesion with EIT depends on difference between electrical impedance of targeted tissue and its surroundings. Therefore, finding a contrast agent for EIT that increase this difference could improve its ability for detection of lesions in early stages. In this study, ability of gold nanoparticles (GNP) to use as EIT contrast agent was investigated. Materials and Methods: Turkevich method was used to synthesis spherical shaped GNPs with the size of 20-25 nm. Characterization of size distribution and shape of synthesized NPs were determined by transmission electron microscopy (TEM). Two types of phantoms (chicken fat and muscle paste tissues) were prepared and their electrical impedance was measured by the 4- electrode method. These measurements were done with and without the presence of GNPs. Results: Results show that presence of gold nanoparticles leads to descending in electrical impedance of tissues. This effect is more significant in frequencies below 1 KHz and has different values for the fat and muscle tissues. Reduction in resistive impedance is about 40.24W and1.93W for fat and muscle tissues at frequency 1 KHz, respectively. Increase in EIT signal is a consequence of reduction in electrical impedance. Consequently, presence of GNPs enhances the EIT signal and this enhancement is different for the fat and muscle tissues. Conclusion: As signal enhancement is different for fat and muscle tissues, gold nanoparticles could be considered as EIT contrast agent to improve detection of abnormalities at early stages. | ||
| کلیدواژهها | ||
| Contrast Agent؛ Conductance؛ Electrical Impedance Imaging؛ Gold Nanoparticle؛ Tissue Equivalent Phantom | ||
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