Azimian, Hosein, Bahreyni Toossi, Mohammad Taghi, Dayyani, Mahdieh, Mahmoudi, Mahmoud. (1397). Use of Apoptotic Biomarkers to Predict Response to Radiotherapy in Breast Cancer Patients. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 42-42. doi: 10.22038/ijmp.2018.11944
Hosein Azimian; Mohammad Taghi Bahreyni Toossi; Mahdieh Dayyani; Mahmoud Mahmoudi. "Use of Apoptotic Biomarkers to Predict Response to Radiotherapy in Breast Cancer Patients". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 42-42. doi: 10.22038/ijmp.2018.11944
Azimian, Hosein, Bahreyni Toossi, Mohammad Taghi, Dayyani, Mahdieh, Mahmoudi, Mahmoud. (1397). 'Use of Apoptotic Biomarkers to Predict Response to Radiotherapy in Breast Cancer Patients', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 42-42. doi: 10.22038/ijmp.2018.11944
Azimian, Hosein, Bahreyni Toossi, Mohammad Taghi, Dayyani, Mahdieh, Mahmoudi, Mahmoud. Use of Apoptotic Biomarkers to Predict Response to Radiotherapy in Breast Cancer Patients. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 42-42. doi: 10.22038/ijmp.2018.11944

Use of Apoptotic Biomarkers to Predict Response to Radiotherapy in Breast Cancer Patients

Iranian Journal of Medical Physics
مقاله 43، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 42-42
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.11944
نویسندگان
Hosein Azimian1؛ Mohammad Taghi Bahreyni Toossi* 2؛ Mahdieh Dayyani3؛ Mahmoud Mahmoudi4
1Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran
2Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3Reza Radiotherapy Oncology Center, Mashhad, Iran
4Immunology Research Center, Bu-Ali Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: To enhance radiation therapy efficiency it is crucial to implement an
individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis pathway on radiosensitivity and normal tissue complications caused by the radiotherapy.
 
Materials and Methods: radiation-induced apoptosis in peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients was examined using the relative quantitative RT-PCR. Expression levels of Bax, Bcl-2, and Bax/Bcl-2 ratio (as an in-vitro radiosensitivity index (RSI)) were examined in in-vitro irradiated (1 and 2 Gy) cells. All the patients received similar tangential irradiation of the whole breast and conventional fractionation and then, Clinical radiosensitivity (as a clinical radiosensitivity index) was determined using the acute reactions to radiotherapy of the skin according to RTOG score. All statistical analyses were performed using GraphPad Prism, version 7.01.
Results: The notable result was a significant correlation between dose-response curve slope (in-vitro RSI) and acute skin toxicity score following irradiation (clinical RSI).
Conclusion: These data suggest that Bax/Bcl-2 ratio determination before radiation therapy can be used as a potential biomarker to identify radiosensitive individuals. However, further studies are required to validate radiation-induced apoptotic biomarkers.
کلیدواژه‌ها
Personalized Medicine؛ Breast Cancer؛ Radiotherapy؛ Radiation Sensitivity
آمار
تعداد مشاهده مقاله: 569
دانشگاه علوم پزشکی مشهد
آمار
تعداد نشریات29
تعداد شماره‌ها2,324
تعداد مقالات24,864
تعداد مشاهده مقاله82,812,701
تعداد دریافت فایل اصل مقاله45,865,544
اخبار نشریات