Sabery Balajaddeh, Fateme, Golshanian, Mohadeseh, Zanganeh, Vahid. (1397). Optimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method. , 15(Special Issue-12th. Iranian Congress of Medical Physics), 36-36. doi: 10.22038/ijmp.2018.11930
Fateme Sabery Balajaddeh; Mohadeseh Golshanian; Vahid Zanganeh. "Optimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method". , 15, Special Issue-12th. Iranian Congress of Medical Physics, 1397, 36-36. doi: 10.22038/ijmp.2018.11930
Sabery Balajaddeh, Fateme, Golshanian, Mohadeseh, Zanganeh, Vahid. (1397). 'Optimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method', , 15(Special Issue-12th. Iranian Congress of Medical Physics), pp. 36-36. doi: 10.22038/ijmp.2018.11930
Sabery Balajaddeh, Fateme, Golshanian, Mohadeseh, Zanganeh, Vahid. Optimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method. , 1397; 15(Special Issue-12th. Iranian Congress of Medical Physics): 36-36. doi: 10.22038/ijmp.2018.11930

Optimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method

Iranian Journal of Medical Physics
مقاله 36، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 36-36
نوع مقاله: Conference Proceedings
شناسه دیجیتال (DOI): 10.22038/ijmp.2018.11930
نویسندگان
Fateme Sabery Balajaddeh1؛ Mohadeseh Golshanian2؛ Vahid Zanganeh* 1
1Department of physics, Sciences Facility, Golestan University P. O. Box 49138-15759, Gorgan, Iran.
2Department of reactor, nuclear science and technology research institute, Tehran, Iran
چکیده
Introduction: Recently head and neck cancer has pay attention to many researchers. Its therapeutic methods include surgery, chemotherapy, radiotherapy and Boron neutron capture therapy (BNCT). BNCT is better than conventional radiotherapy because it targets the tumor cell. This method involves two steps of infusion of stable 10B and then neutron radiation with a suitable intensity and energy.
The BNCT in combination with boronphenylalanine (BPA) and borocaptate sodium (BSH) that was make using the epithermal neutron. BSH and PBA are used as 10B carriers. Epithermal neutrons reach to thermal transiting through tissues of the body. When 10B absorbed thermal neutrons, the α and 7Li particles produced in the 10B (n, α) 7Li reaction are of high linear energy. Transfer radiation have a short range of one cell diameter.
Materials and Methods: Monte Carlo simulations were performed with MCNPX2.6 and RO31 MIRD phantom. The neutron source was employed the surface disk with 10 diameters and the range of energy was considered from 1ev-10Kev. The results of neutron and gamma dose at various depths was calculated using tally F4 and F6 in MCNPX2.6 code.
Results: Relative Dose was obtained at various depths based on energy changes for gamma, fast and thermal neutron.
The results of this study have shown increases of optimum energy as the tumor get deeper respect to the skin. In addition, an analytical relation was proposed for energy optimization with the position of the tumor.
Conclusion: The optimum neutron energy dependence was investigated for neck tumor in different depths. These results provide useful information to the physicians to choice best optimum energy neutron beam in BNCT method.
کلیدواژه‌ها
Boron neutron capture therapy (BNCT)؛ Optimize energy relative to depth at BNCT؛ Gamma and fast neutron doses
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