Comparison and evaluation of dosimetric and radiobiological parameters in two different treatment plans in stomach cancer by use of 3D CRT | ||
| Iranian Journal of Medical Physics | ||
| مقاله 34، دوره 15، Special Issue-12th. Iranian Congress of Medical Physics، بهمن و اسفند 2018، صفحه 34-34 | ||
| نوع مقاله: Conference Proceedings | ||
| شناسه دیجیتال (DOI): 10.22038/ijmp.2018.11889 | ||
| نویسندگان | ||
| Maryam Rezaie Yazdi1؛ Malihe Rezaie Yazdi1؛ Kaveh Shirani Tak Abi* 2؛ Hassan Ali Nedaie3؛ Narges Kheirollahi4؛ Payam Izadpanahi5؛ Reza KhodaBakhshi6؛ Farid Nezhad Dadgar7 | ||
| 1Medical physicist of Iran Mehr Radiotherapy Oncology Department, Iran Mehr Hospital, Birjand, Iran. | ||
| 2Medical Physicist of Sina Radiotherapy Oncology Department, Bu Ali Hospital, Tehran, Iran. | ||
| 3Assistant Prof. of Medical Physics, Radiotherapy Oncology Department, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 4Medical physicist of Imam Reza Radiotherapy Oncology Department, Imam Reza Hospital, Mashhad, Iran. | ||
| 5Radiation Oncologist of Iran Mehr Radiotherapy Oncology Department, Iran Mehr Hospital, Birjand, Iran. | ||
| 6Radiation Oncologist, Consultant and Executive Director of Sina Radiotherapy Oncology Department, Bu Ali Hospital, Tehran, Iran. | ||
| 7Assistance Prof. of Radiation Oncology, Sina Radiotherapy Oncology Department, Bu Ali Hospital, Islamic Azad University, Medical College, Tehran, Iran. | ||
| چکیده | ||
| Introduction: In 3DCRT the number of therapeutic fields has dramatic impact on treatment results especially in stomach cancer. Traditionally, for radiotherapy of stomach cancer the therapeutic procedure was using two fields (AP- PA or AP Lateral with wedge) to achieve smooth and homogeneous dose distribution in tumor. But nowadays, adding lateral or oblique fields to aforementioned techniques lead to reducing dose to organ at risks (OARs) like spinal cord, liver, both kidneys and better dose distribution in tumor. Moreover, there are a several ways to evaluate traditional and novel techniques in 3DCRT for stomach cancer. for example, Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) from radiobiological point of view and Homogeneity Index (HI), Conformity Index (CI) as a dosimetric parameters. Thus, the aim of this study is to assess and compare two different plans in stomach cancer by using homogeneity Index, conformity index, TCP and NTCP as guidance criteria in 3DCRT. Materials and Methods: In this study, 10 patients with stomach cancer were chosen. Two different of treatment plans; three fields (AP, PA, and lateral) and four fields (AP, PA and two laterals) were prepared. A photon beam of 6MV quality was used for both treatment plans in PCRT 3D as treatment planning system. Prescribed dose was 5o.4 Gy for tumor. Therapeutic aim for all treatment plans was to deliver at least 95% of prescribed dose to 97% of target volume while sparing organ at risks. The normalization of each plan followed the recommendation of ICRU report 50. The tumor volume selected for calculating the HI, CI and TCP and OARs for NTCP. Results:Average ratio of the calculated parameters in treatment plans of four fields over three fields with standard deviation (Mean /SD) was 1.05±0.13 for CI and 0.99±0.01 for HI. In addition, Treatment ratio for four fields over three fields was 1±0.02. Damage ratio to spinal cord and liver was 0.57±0.18 and 2.09±0.93 respectively for treatment plans with four fields in comparison of treatment plans by using of three therapeutic fields. Conclusion: Results show that, HI and CI parameters are approximately equal in two treatment plans. Therefore, both of the treatment plans are acceptable for clinical use. Assessment TCP and NTCP radiobiology parameter determined that, tumor control probability for both treatment plans are same but, damage probability of liver in three field treatment plan is less than over four fields while damage probability of spinal cord in four field treatment plan is lower than three fields treatment planning. | ||
| کلیدواژهها | ||
| Conformity Index؛ Homogeneity Index؛ TCP؛ NTCP؛ Stomach Cancer | ||
|
آمار تعداد مشاهده مقاله: 689 |
||
| تعداد نشریات | 29 |
| تعداد شمارهها | 2,324 |
| تعداد مقالات | 24,864 |
| تعداد مشاهده مقاله | 82,812,701 |
| تعداد دریافت فایل اصل مقاله | 45,865,544 |