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Ahmadian, Nahid, Mahmoudi, Javad, Talebi, Mahnaz, Molavi, Leila, Sadigh-Eteghad, saeed, Rostrup, Egill, Ziaee, Mojtaba. (1397). Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats. , 21(12), 1289-1296. doi: 10.22038/ijbms.2018.28546.6919
Nahid Ahmadian; Javad Mahmoudi; Mahnaz Talebi; Leila Molavi; saeed Sadigh-Eteghad; Egill Rostrup; Mojtaba Ziaee. "Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats". , 21, 12, 1397, 1289-1296. doi: 10.22038/ijbms.2018.28546.6919
Ahmadian, Nahid, Mahmoudi, Javad, Talebi, Mahnaz, Molavi, Leila, Sadigh-Eteghad, saeed, Rostrup, Egill, Ziaee, Mojtaba. (1397). 'Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats', , 21(12), pp. 1289-1296. doi: 10.22038/ijbms.2018.28546.6919
Ahmadian, Nahid, Mahmoudi, Javad, Talebi, Mahnaz, Molavi, Leila, Sadigh-Eteghad, saeed, Rostrup, Egill, Ziaee, Mojtaba. Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats. , 1397; 21(12): 1289-1296. doi: 10.22038/ijbms.2018.28546.6919

Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 21، شماره 12، اسفند 2018، صفحه 1289-1296    اصل مقاله (586.39 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.28546.6919
نویسندگان
Nahid Ahmadian1، 2؛ Javad Mahmoudi* 1؛ Mahnaz Talebi1؛ Leila Molavi3؛ saeed Sadigh-Eteghad1؛ Egill Rostrup4؛ Mojtaba Ziaee5
1Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Molecular Medicine, Faculty of Advanced Biomedical Sciences, Tabriz, Iran
3Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
4Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark
5Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Objective(s): The present study was conducted to examine the effect of sleep deprivation (SD) on the anti-apoptotic pathways in Parkinsonian rats.
Materials and Methods: Male Wistar rats (n = 40) were assigned to four groups (10 animals each): sham surgery (Sham), 6-hydroxydopamine (6-OHDA)-lesioned (OH), 6-OHDA-lesioned plus grid control (OH+GC), 6-OHDA-lesioned plus SD (OH+SD). Parkinson’s disease (PD) model was induced by the unilateral intra-striatal infusion of 6-OHDA (10 µg/rat). SD (4 hr/day, for 14 days) was induced using a multiple platforms water tank. On the last day of interventions, animals were subjected to open field test for horizontal motor performance assessment. Also, brain-derived neurotrophic factor (BDNF), Bcl-2 and Bax were assessed in the striatum of study groups.
Results: SD obscured the motor deficits of PD animals observed in open field test. BDNF level and Bcl2/Bax ratio significantly increased in the OH group, and SD reduced their levels in the PD animals.
Conclusion: SD suppressed the anti-apoptotic compensatory responses in the striatum; therefore, it may accelerate continual neuronal cell death in PD.
کلیدواژه‌ها
Bcl-2؛ BDNF؛ Bax؛ Sleep deprivation؛ Parkinson’s disease؛ 6-Hydroxy dopamine
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