سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Wang, Huimei, Khoradmehr, Arezoo, Jalali, Mohammad, Salehi, Mohammad Saied, Tsutsui, Kazuyoshi, Jafarzadeh Shirazi, Mohammad Reza, Tamadon, Amin. (1397). The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction. , 21(12), 1210-1220. doi: 10.22038/ijbms.2018.30520.7355
Huimei Wang; Arezoo Khoradmehr; Mohammad Jalali; Mohammad Saied Salehi; Kazuyoshi Tsutsui; Mohammad Reza Jafarzadeh Shirazi; Amin Tamadon. "The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction". , 21, 12, 1397, 1210-1220. doi: 10.22038/ijbms.2018.30520.7355
Wang, Huimei, Khoradmehr, Arezoo, Jalali, Mohammad, Salehi, Mohammad Saied, Tsutsui, Kazuyoshi, Jafarzadeh Shirazi, Mohammad Reza, Tamadon, Amin. (1397). 'The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction', , 21(12), pp. 1210-1220. doi: 10.22038/ijbms.2018.30520.7355
Wang, Huimei, Khoradmehr, Arezoo, Jalali, Mohammad, Salehi, Mohammad Saied, Tsutsui, Kazuyoshi, Jafarzadeh Shirazi, Mohammad Reza, Tamadon, Amin. The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction. , 1397; 21(12): 1210-1220. doi: 10.22038/ijbms.2018.30520.7355

The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction

Iranian Journal of Basic Medical Sciences
مقاله 3، دوره 21، شماره 12، اسفند 2018، صفحه 1210-1220    اصل مقاله (721.03 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.30520.7355
نویسندگان
Huimei Wang1؛ Arezoo Khoradmehr2؛ Mohammad Jalali3؛ Mohammad Saied Salehi4؛ Kazuyoshi Tsutsui5؛ Mohammad Reza Jafarzadeh Shirazi6؛ Amin Tamadon* 3
1Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences; Institute of Acupuncture and Moxibustion, Fudan Institutes of Integrative Medicine, Fudan University, Shanghai, China
2Research and Clinical Center for Infertility, Yazd Reproduction Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
4Department of Physiology, Faculty of Biological Sciences and Technology, Shahid Beheshti University, Tehran, Iran
5Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Tokyo, Japan
6Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran
چکیده
Objective(s): To benefit from reproduction and deal with challenges in the environmental conditions, animals must adapt internal physiology to maximize the reproduction rate. Maladaptive variations in the neurochemical systems and reproductive system can lead to manifestation of several significant mammalian reprocesses, including mammalian ovarian lifespan. RFamide-related peptide (RFRP, Rfrp), mammalian orthologues of gonadotropin-inhibitory hormone (GnIH), which is a regulator to prevent the gonadotropin-releasing hormone (GnRH) neural activity, is known to be related to reproductive traits. This review aimed to summarize recent five-year observations to outline historic insights and novel perspectives into the functions of RFRPs in coding the mammalian reproductive physiology, especially highlight recent advances in the impact on RFRPs in regulating mammalian ovary lifespan.
Materials and Methods: We reviewed the recent five-year important findings of RFRP system involved in mammalian ovary development. Data for this review were collected from Google Scholar and PubMed using the RFRP keyword combined with the keywords related to physiological or pathological reproductive functions.
Results: Recent discoveries are focused on three major fronts in research on RFRP role in female reproduction including reproductive functions, energy balance, and stress regulation. The roles of RFRPs in various development phases of mammal reproduction including prepuberty, puberty, estrous cycle, pregnancy, milking, menopause, and/or ovarian diseases have been shown.
Conclusion: Overall, these recent advances demonstrate that RFRPs serve as critical mediators in mammalian ovarian development.
کلیدواژه‌ها
Female؛ Gonadotropin-inhibitory؛ hormone؛ Mammals؛ RFamide-related peptide؛ Reproduction
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