Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 12، دوره 21، شماره 11، بهمن 2018، صفحه 1174-1178 اصل مقاله (782.59 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2018.30371.7322 | ||
| نویسندگان | ||
| Cheng-Hang Ko1؛ Chun-Ping Huang2؛ Yi-Wen Lin2، 3؛ Ching-Liang Hsieh* 1، 2، 3، 4 | ||
| 1Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan | ||
| 2Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan | ||
| 3Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan | ||
| 4Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan | ||
| چکیده | ||
| Objective(s): Paeoniflorin (PF) has anti-oxidation, anti-inflammation, anti-apoptosis, and neuroprotection pharmacological effects against ischemic injury. The aim of the present study was to investigate the neuroprotection mechanisms of PF in cerebral ischemia-reperfusion injury rats. Materials and Methods: We established an animal model of cerebral infarct by occlusion of the middle cerebral artery for 15 min, followed by reperfusion, and PF was administered 24 hr later (20 mg/kg, intraperitoneally for 6 days) after reperfusion Results: Treatment with PF reduced the neurological deficit score, improved motor function, decreased cell counts of nicotinic acetylcholine receptor (nAChR) α4β2 immunoreactive cells, and increased cell counts of nAChR α7. Furthermore, PF administration suppressed neuronal apoptosis and promoted neurogenesis. Conclusion: PF rescued neurological deficit and underlying mechanisms were inhibition of neurological apoptosis and inflammation by nAChRs. | ||
| کلیدواژهها | ||
| Apoptosis؛ Inflammation؛ Neurogenesis؛ Nicotinic acetylcholine receptor؛ Paeoniflorin؛ Stroke | ||
| مراجع | ||
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