Topical application of Cassia fistula L. fruit gel in management of cutaneous lesions of pemphigus vulgaris: A double-blind, placebo-controlled clinical trial | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 9، دوره 8، شماره 6، بهمن و اسفند 2018، صفحه 543-551 اصل مقاله (556.49 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2018.11515 | ||
| نویسندگان | ||
| Fatemh Atarzadeh1؛ Mohammad Kamalinejad2؛ Gholam reza Amin3؛ Ali reza Salehi4؛ Ladan dastgheib* 5؛ Amir Mohammad Jaladat6؛ Mojtaba Heydari6؛ Zahra Gouyandeh5 | ||
| 1Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Traditional Iranian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 3Department of Pharmacognosy and Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Objective: Cassia fistula L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of C. fistula fruit gel on healing time of PV lesions in a clinical setting. Materials and Methods: This was a randomized, double-blind placebo-controlled clinical trial that was performed in dermatology ward at Saadi hospital, affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Right- or left- sided lesions of PV patients on standard systemic treatment were randomized for treatment with either C. fistula fruit gel or placebo prescribed twice daily. The largest diameter of each lesion was measured at the baseline (day 0) and on days 10 and 20. Epithelialization Index (EI), as outcome measure was calculated and compared between the two groups. Results: The present study comprised 20 patients, with overall 82 cutaneous lesions including 41 lesions in the C. fistula fruit gel group and 41 lesions in the placebo group. The EI in the C. fistula fruit gel group was significantly higher than that of the placebo group both on day 10 (65±28vs 30±34; p=0.001) and at the end of the study (91±22 vs 69±49; p=0.003). Conclusion: Topical application of C. fistula fruit gel can be considered as an effective adjuvant therapy in treatment of PV. | ||
| کلیدواژهها | ||
| Cassia fistula L؛ Pemphigus vulgaris؛ Traditional Persian Medicine؛ Topical therapy | ||
| مراجع | ||
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