CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 14، دوره 21، شماره 11، بهمن 2018، صفحه 1186-1191 اصل مقاله (982.22 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2018.30347.7313 | ||
| نویسندگان | ||
| Shao-Bo Ouyang1؛ Jun Wang2؛ Si-Yu Zhao1؛ Xian-Hua Zhang1؛ Lan Liao* 1 | ||
| 1Department of Oral Prosthodontics, the Affiliated Stomatological Hospital of Nanchang University, Jiangxi Provincial Key Laboratory of Oral Biomedicine, Nanchang 330006, China | ||
| 2Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China | ||
| چکیده | ||
| Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression profile of circRNAs in OSCC tumor tissues was performed by high-throughput sequencing. The CCK-8 wound healing and apoptosis assay were measured in OSCC cell lines after transfection with si-0109291 or si-NC. Results: We discovered that hsa_circ_0109291 was significantly increased in OSCC tissues and cell lines compared with their corresponding control group. Knockdown of hsa_circ_0109291 inhibited proliferation and migration of OSCC cell lines in vitro. In addition, inhibition of hsa_circ_0109291 dramatically induced apoptosis of OSCC cells. We further found that high hsa_circ_0109291 levels in OSCC patients resulted in a poorer prognosis than in patients with low hsa_circ_0109291 levels. Conclusion: These findings indicated that hsa_circ_0109291 correlated with the progression of OSCC and might be a new therapeutic target for the treatment of OSCC. | ||
| کلیدواژهها | ||
| Apoptosis؛ CircRNA؛ Hsa_circ_0109291؛ Oral squamous cell carcinoma؛ Prognosis | ||
| مراجع | ||
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