سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mahesh Kumar, Puttanarasaiah, Venkataranganna, Marikunte V, Manjunath, Kirangadur, Viswanatha, Gollapalle Lakshminarayanashastry, Ashok, Godavarthy. (1397). Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice. , 21(10), 1083-1090. doi: 10.22038/ijbms.2018.29354.7095
Puttanarasaiah Mahesh Kumar; Marikunte V Venkataranganna; Kirangadur Manjunath; Gollapalle Lakshminarayanashastry Viswanatha; Godavarthy Ashok. "Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice". , 21, 10, 1397, 1083-1090. doi: 10.22038/ijbms.2018.29354.7095
Mahesh Kumar, Puttanarasaiah, Venkataranganna, Marikunte V, Manjunath, Kirangadur, Viswanatha, Gollapalle Lakshminarayanashastry, Ashok, Godavarthy. (1397). 'Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice', , 21(10), pp. 1083-1090. doi: 10.22038/ijbms.2018.29354.7095
Mahesh Kumar, Puttanarasaiah, Venkataranganna, Marikunte V, Manjunath, Kirangadur, Viswanatha, Gollapalle Lakshminarayanashastry, Ashok, Godavarthy. Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice. , 1397; 21(10): 1083-1090. doi: 10.22038/ijbms.2018.29354.7095

Momordica cymbalaria fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice

Iranian Journal of Basic Medical Sciences
مقاله 15، دوره 21، شماره 10، دی 2018، صفحه 1083-1090    اصل مقاله (1.02 M)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.29354.7095
نویسندگان
Puttanarasaiah Mahesh Kumar1؛ Marikunte V Venkataranganna2؛ Kirangadur Manjunath3؛ Gollapalle Lakshminarayanashastry Viswanatha* 4؛ Godavarthy Ashok5
1Department of Biotechnology, Padmashree Institute of Information Sciences, Bengaluru, Karnataka, India
2Connexios Life Sciences Pvt. Ltd., Bengaluru, Karnataka, India
3Department of Microbiology and Biotechnology, Bangalore University, Bengaluru, Karnataka, India
4Independent Researcher, Kengeri, Bangalore, Karnataka, India
5Radiant Research Services Pvt. Ltd., Bengaluru, Karnataka, India
چکیده
Objective(s): The present study was aimed to evaluate the effect of methanolic fruit extract of Momordica cymbalaria (MeMC) against high-fat diet-induced obesity and diabetes in C57BL/7 mice.
Materials and Methods: In the present study, six weeks old male C57BL/6 mice were divided into four groups. G-1 and G-2 served as lean control and HFD control, G-3 and G-4 received MeMC 25 and 50 mg/kg, BW doses; all the treatments were given for a period of 11 weeks. The parameters such as body weight, fasting blood glucose, insulin, cholesterol, free fatty acid, and oral glucose tolerance tests were performed, further, at the end of the study fasting body weight, and weights of organs such as the liver, heart, and adipose tissue were measured and the liver tissue was subjected to histopathology evaluation, and insulin resistance was expressed as HOMA-IR index.
Results: The high-fat diet fed C57 mice showed significant elevation of body weight (P<0.01), blood glucose (P<0.01), insulin (P<0.01), cholesterol (P<0.01), free fatty acid (P<0.01), and HOMA-IR index (P<0.01) along with significant elevation of all organ weights and reduction in oral glucose tolerance (P<0.01) and brown adipose weight (P<0.01). The histopathology showed significant fatty infiltration and hypertrophy of hepatocytes. Interestingly, MeMC (50 mg/kg) alleviated all the HFD-induced perturbances significantly. Further, the HPLC analysis of MeMC revealed the presence of gallic acid and rutin as chief ingredients.
Conclusion: MeMC possesses potent antidiabetic activity and ameliorates insulin resistance in HFD diet fed C57 mice.
کلیدواژه‌ها
C57BL/6 mice؛ Diabetes؛ Herbal Medicine؛ High-fat diet؛ insulin resistance؛ M. cymbalaria
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