سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Pirzad Jahromi, Gila, Shabanzadeh Pirsaraei, Alireza, Mokhtari Hashtjini, Mina, Sadr, Seyed Shahabeddin, Rasouli Vani, Javad, Raouf Sarshoori, Javad, Charish, Jason. (1397). Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke. , 21(10), 1004-1012. doi: 10.22038/ijbms.2018.29382.7100
Gila Pirzad Jahromi; Alireza Shabanzadeh Pirsaraei; Mina Mokhtari Hashtjini; Seyed Shahabeddin Sadr; Javad Rasouli Vani; Javad Raouf Sarshoori; Jason Charish. "Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke". , 21, 10, 1397, 1004-1012. doi: 10.22038/ijbms.2018.29382.7100
Pirzad Jahromi, Gila, Shabanzadeh Pirsaraei, Alireza, Mokhtari Hashtjini, Mina, Sadr, Seyed Shahabeddin, Rasouli Vani, Javad, Raouf Sarshoori, Javad, Charish, Jason. (1397). 'Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke', , 21(10), pp. 1004-1012. doi: 10.22038/ijbms.2018.29382.7100
Pirzad Jahromi, Gila, Shabanzadeh Pirsaraei, Alireza, Mokhtari Hashtjini, Mina, Sadr, Seyed Shahabeddin, Rasouli Vani, Javad, Raouf Sarshoori, Javad, Charish, Jason. Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke. , 1397; 21(10): 1004-1012. doi: 10.22038/ijbms.2018.29382.7100

Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 21، شماره 10، دی 2018، صفحه 1004-1012    اصل مقاله (959.21 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.29382.7100
نویسندگان
Gila Pirzad Jahromi1؛ Alireza Shabanzadeh Pirsaraei* 2، 3؛ Mina Mokhtari Hashtjini2؛ Seyed Shahabeddin Sadr2، 3؛ Javad Rasouli Vani4؛ Javad Raouf Sarshoori5؛ Jason Charish6
1Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Electrophysiology Research Centre, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
3Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran,
4Departmentof Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
5Department of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
6Genetics and Development Division, Krembil Research Institute, Toronto, ON, Canada
چکیده
Objective(s): The beneficial outcomes of bone marrow-derived mesenchymal stem cell (BMSC) treatment on functional recovery following stroke has been well established. Furthermore, 5-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have also been shown to increase neuronal survival and promote the movement of BMSCs towards the sites of inflammation. However, the precise mechanisms mediating the improved neurological functional recovery in stoke models following a combination treatment of Simvastatin and BMSCs still remained poorly understood.
Materials and Methods: Here, an embolic stroke model was used to experimentally induce a focal ischemic brain injury by inserting a preformed clot into the middle cerebral artery (MCA). Following stroke, animals were treated either with an intraperitoneal injection of Simvastatin, an intravenous injection of 3 ×106 BMSCs, or a combination of these two treatments.
Results: Seven days after ischemia, the combination of Simvastatin and BMSCs led to a significant increase in BMSC relocation, endogenous neurogenesis, arteriogenesis and astrocyte activation while also reducing neuronal damage when compared to BMSC treatment alone (PConclusion: These results further demonstrate the synergistic benefits of a combination treatment and help to improve our understanding of the underlying mechanisms mediating this beneficial effect.
کلیدواژه‌ها
Behavioral assessment؛ Bone marrow stromal cell؛ Brain؛ c-Fos؛ Ischemic stroke؛ Simvastatin
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