سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mirshekar, Mohammad Ali, Sarkaki, Alireza, Farbood, Yaghoob, Gharib Naseri, Mohammad Kazem, Badavi, Mohammad, Mansouri, Mohamad Taghi, Haghparast, Abbas. (1397). Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies. , 21(10), 1056-1063. doi: 10.22038/ijbms.2018.29639.7165
Mohammad Ali Mirshekar; Alireza Sarkaki; Yaghoob Farbood; Mohammad Kazem Gharib Naseri; Mohammad Badavi; Mohamad Taghi Mansouri; Abbas Haghparast. "Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies". , 21, 10, 1397, 1056-1063. doi: 10.22038/ijbms.2018.29639.7165
Mirshekar, Mohammad Ali, Sarkaki, Alireza, Farbood, Yaghoob, Gharib Naseri, Mohammad Kazem, Badavi, Mohammad, Mansouri, Mohamad Taghi, Haghparast, Abbas. (1397). 'Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies', , 21(10), pp. 1056-1063. doi: 10.22038/ijbms.2018.29639.7165
Mirshekar, Mohammad Ali, Sarkaki, Alireza, Farbood, Yaghoob, Gharib Naseri, Mohammad Kazem, Badavi, Mohammad, Mansouri, Mohamad Taghi, Haghparast, Abbas. Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies. , 1397; 21(10): 1056-1063. doi: 10.22038/ijbms.2018.29639.7165

Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies

Iranian Journal of Basic Medical Sciences
مقاله 11، دوره 21، شماره 10، دی 2018، صفحه 1056-1063    اصل مقاله (746.83 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.29639.7165
نویسندگان
Mohammad Ali Mirshekar1، 2؛ Alireza Sarkaki* 1، 3؛ Yaghoob Farbood1، 3؛ Mohammad Kazem Gharib Naseri3؛ Mohammad Badavi1، 3؛ Mohamad Taghi Mansouri3، 4؛ Abbas Haghparast5
1Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Department of Physiology, School of Medicine and Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
3Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4Department of Pharmacology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI.  In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiation (LTP) from hippocampal dentate gyrus (hDG), brain lipid peroxidation and cytokines after TBI were evaluated.
Materials and Methods: Seventy-two adult male Wistar rats divided randomly into three groups with 24 in each: Veh + Sham, Veh + TBI and GA + TBI (GA; 100 mg/kg, PO for 7 days before TBI induction). Brain injury was made by Marmarou’s method. Briefly, a 200 g weight was fallen down from a 2 m height through a free-falling tube onto the head of anesthetized animal.
Results: Veterinary coma scores (VCS), memory and recorded hDG -LTP significantly reduced in Veh + TBI group at 1 and 24 hr after TBI when compared to Veh + Sham (P<0.001), respectively, while brain tissue content of interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA) were increased significantly (P<0.001). Pretreatment of TBI rats with GA improved clinical signs, memory and hDG-LTP significantly (P<0.001) compared to Veh + TBI group, while brain tissue content of IL-1β, IL-6, TNF-α and MDA were decreased significantly (P<0.001).
Conclusion: Our results propose that GA has neuroprotective effect on memory and LTP impairment due to TBI through decrement of brain lipid peroxidation and cerebral pro-inflammatory cytokines.
کلیدواژه‌ها
Brain inflammation؛ Gallic acid؛ Long-term potentiation؛ Memory؛ Rat؛ Traumatic brain injury
مراجع
1. Brooks JC, Strauss DJ, Shavelle RM, Paculdo DR, Hammond FM, Harrison-Felix CL. Long-term disability and survival in traumatic brain injury: results from the national institute on disability and rehabilitation research model systems. Arch Phys Med Rehabil 2013; 94:2203-2209.
2. Faul M, Xu L, Wald M, Coronado VG. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Traumatic brain injury in the United States: emergency department visits, hospitalizations and deaths 2002–2006. 2010;2-70.
3. Wang KK, Larner SF, Robinson G, Hayes RL. Neuroprotection targets after traumatic brain injury. Curr Opin Neurol 2006; 19:514-519.
4. Kumar A, Loane DJ. Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun 2012; 26:1191-201.
5. Ozen LJ, Fernandes MA. Slowing down after a mild traumatic brain injury: a strategy to improve cognitive task performance. Arch Clin Neuropsychol 2012; 27:85-100.
6. Trivedi MA, Ward MA, Hess TM, Gale SD, Dempsey RJ, Rowley HA, et al. Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma. J Neurotrauma 2007; 24:766-771.
7. Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth 2007; 99:4-9.
8. Greenberg G, Mikulis DJ, Ng K, DeSouza D, Green RE. Use of diffusion tensor imaging to examine subacute white matter injury progression in moderate to severe traumatic brain injury. Arch Phys Med Rehabil 2008; 89:45-50.
9. Deadwyler SA, Bunn T, Hampson RE. Hippocampal ensemble activity during spatial delayed-nonmatch-to-sample performance in rats. J Neurosci 1996; 16:354-372.
10. Collingridge G, Bliss T. Memories of NMDA receptors and LTP. Trends Neurosci 1995; 18:54-56.
11. Sirota L, Shacham D, Punsky I, Bessler H. Ibuprofen affects pro-and anti-inflammatory cytokine production by mononuclear cells of preterm newborns. Biol Neonate 2001; 79:103-108.
12. Sarkaki AR, Khaksari Haddad M, Soltani Z, Shahrokhi N, Mahmoodi M. Time-and dose-dependent neuroprotective effects of sex steroid hormones on inflammatory cytokines after a traumatic brain injury. J Neurotrauma 2013; 30:47-54.
13. Qi FH, Jing TZ, Wang ZX, Zhan YG. Fungal endophytes from Acer ginnala Maxim: isolation, identification and their yield of gallic acid. Lett Appl Microbiol 2009; 49:98-104.
14. Kratz JM, Andrighetti-Frohner CR, Leal PC, Nunes RJ, Yunes RA, Trybala E, et al. Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate. Biol Pharm Bull 2008; 31:903-907.
15. Kratz JM, Andrighetti-Frohner CR, Kolling DJ, Leal PC, Cirne-Santos CC, Yunes RA, et al. Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate. Mem Inst Oswaldo Cruz 2008; 103:437-442.
16. Kim YJ. Antimelanogenic and antioxidant properties of gallic acid. Biol Pharm Bull 2007; 30:1052-1055.
17. Mansouri MT, Farbood Y, Sameri MJ, Sarkaki A, Naghizadeh B, Rafeirad M. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chem 2013; 138:1028-1033.
18. Sarkaki A, Farbood Y, Gharib-Naseri MK, Badavi M, Mansouri MT, Haghparast A, et al. Gallic acid improved behavior, brain electrophysiology, and inflammation in a rat model of traumatic brain injury. Can J Physiol Pharmacol 2015; 93:687-694.
19. Mansouri MT, Farbood Y, Sameri MJ, Sarkaki A, Naghizadeh B, Rafeirad M. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chem 2013; 138:1028-1033.
20. Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005; 81:230S-242S.
21. O’Connor CA, Cernak I, Vink R. Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats. Brain Res 2005; 1062:171-174.
22. King DR, Cohn SM, Proctor KG. Changes in intracranial pressure, coagulation, and neurologic outcome after resuscitation from experimental traumatic brain injury with hetastarch. Surgery 2004; 136:355-363.
23. Lashgari R, Motamedi F, Zahedi Asl S, Shahidi S, Komaki A. Behavioral and electrophysiological studies of chronic oral administration of L-type calcium channel blocker verapamil on learning and memory in rats. Behav Brain Res 2006; 171:324-328.
24. Paxinos G, Watson C. The rat brain in stereotaxic coordinates: hard cover edition: Academic press; 2006.
25. Roohbakhsh A, Moghaddam AH, Massoudi R, Zarrindast MR. Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus‐maze test. Clin Exp Pharmacol Physiol 2007; 34:223-229.
26. Sarkaki A, Rafieirad M, Hossini SE, Farbood Y, Motamedi F, Mansouri SMT, et al. Improvement in memory and brain long-term potentiation deficits due to permanent hypoperfusion/ischemia by grape seed extract in rats. Iran J Basic Med Sci 2013; 16:1004-1010.
27. Dubal DB, Wise PM. Neuroprotective effects of estradiol in middle-aged female rats 1. Int J Endocrinol 2001; 142:43-48.
28. Holmin S, Höjeberg B. In situ detection of intracerebral cytokine expression after human brain contusion. Neurosci Lett 2004; 369:108-114.
29. Taupin V, Toulmond S, Serrano A, Benavides J, Zavala F. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion: Influence of pre-and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol 1993; 42:177-185.
30. Rao B, Soufir J, Martin M, David G. Lipid peroxidation in human spermatozoa as relatd to midpiece abnormalities and motility. Gamete Res 1989; 24:127-134.
31. Tate DF, Bigler ED. Fornix and hippocampal atrophy in traumatic brain injury. Learn Mem 2000; 7:442-446.
32. Mashhadizadeh S, Farbood Y, Dianat M, Khodadadi A, Sarkaki A. Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-alpha level in brain due to experimental traumatic brain injury. Iran J Basic Med Sci 2017; 20:399-407.
33. McIntosh T, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, et al. Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 1989; 28:233-244.
34. Lyeth B, Jenkins L, Hamm R, Dixon C, Phillips L, Clifton G, et al. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res 1990; 526:249-258.
35. Hamm RJ, Lyeth BG, Jenkins LW, O’Dell DM, Pike BR. Selective cognitive impairment following traumatic brain injury in rats. Behav Brain Res 1993; 59:169-173.
36. Hicks R, Smith D, Lowenstein D, Marie RS, McIntosh T. Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus. J Neurotrauma 1993; 10:405-414.
37. Bramlett HM, Green EJ, Dietrich WD, Busto R, Globus MY, Ginsberg MD. Posttraumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. J Neurotrauma 1995; 12:289-298.
38. Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev 2007; 54:162-180.
39. Cavaglia M, Dombrowski SM, Drazba J, Vasanji A, Bokesch PM, Janigro D. Regional variation in brain capillary density and vascular response to ischemia. Brain Res 2001; 910:81-93.
40. Yaka R, Biegon A, Grigoriadis N, Simeonidou C, Grigoriadis S, Alexandrovich AG, et al. D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J 2007; 21:2033-2041.
41. Farbood Y, Sarkaki A, Dianat M, Khodadadi A, Haddad MK, Mashhadizadeh S. Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury. Life Sci 2015; 124:120-127.
42. Miyazaki S, Katayama Y, Lyeth B, Jenkins L, Dewitt D, Goldberg S, et al. Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat. Brain Res 1992; 585:335-339.
43. Sanders MJ, Sick TJ, Perez-Pinzon MA, Dietrich WD, Green EJ. Chronic failure in the maintenance of long-term potentiation following fluid percussion injury in the rat. Brain Res 2000; 861:69-76.
44. Albensi BC, Sullivan PG, Thompson MB, Scheff SW, Mattson MP. Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity. Exp Neurol 2000; 162:385-389.
45. Choi DW. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends in Neurosci 1995; 18:58-60.
46. Albensi BC. Models of brain injury and alterations in synaptic plasticity. J Neurosci Res 2001; 65:279-283.
47. de Vries HE, Kuiper J, de Boer AG, Van Berkel TJ, Breimer DD. The blood-brain barrier in neuroinflammatory diseases. Pharmacol Rev 1997; 49:143-156.
48. del Zoppo GJ, Hallenbeck JM. Advances in the vascular pathophysiology of ischemic stroke. Thrombo Res 2000; 98:73-81.
49. Rostworowski M, Balasingam V, Chabot S, Owens T, Yong VW. Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-γ. J Neurosci 1997; 17:3664-3674.
50. Kamm K, Vanderkolk W, Davis AT, Lawrence C, Jonker M. The effect of traumatic brain injury upon the concentration and expression of interleukin-1 and interleukin-10 in the rat. J Trauma 2006; 60:152-157.
51. Lenzlinger PM, Morganti-Kossmann MC, Laurer HL, McIntosh TK. The duality of the inflammatory response to traumatic brain injury. Mol Neurobiol 2001; 24:169-181.
52. Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, et al. Progesterone administration modulates TLRS/NF-κB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci 2008; 38:65-74.
53. Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK. Experimental brain injury induces differential expression of tumor necrosis factor-α mRNA in the CNS. Brain Res Mol Brain Res 1996; 36:287-291.
54. Stein DG, Wright DW, Kellermann AL. Does progesterone have neuroprotective properties?. Ann Emerg Med 2008; 51:164-172.
55. McIntosh TK, Juler M, Wieloch T. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998. J Neurotrauma 1998; 15:731-769.
56. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 2004; 74:2157-2184.
57. De Beer D, Joubert E, Gelderblom WC, Manley M. Antioxidant activity of South African red and white cultivar wines: free radical scavenging. J Agric Food Chem 2003; 5:902-909.
58. Sun J, Chu YF, Wu X, Liu RH. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem 2002; 50:7449-7454.
59. Wolfe K, Wu X, Liu RH. Antioxidant activity of apple peels. J Agric Food Chem 2003; 51:609-614.
60. Yang HL, Chang WH, Chia YC, Huang CJ, Lu FJ, Hsu HK, et al. Toona sinensis extracts induces apoptosis via reactive oxygen species in human premyelocytic leukemia cells. Food Chem Toxicol 2006; 44:1978-1988.
61. Isuzugawa K, Inoue M, Ogihara Y. Catalase contents in cells determine sensitivity to the apoptosis inducer gallic acid. Biol Pharm Bull 2001; 24:1022-1026.    
62. Hang CH, Shi JX, Li JS, Li WQ, Wu W. Expressions of intestinal NF-κB, TNF-α, and IL-6 following traumatic brain injury in rats. J Surg Res 2005; 123:188-193.
63. Morais MC, Luqman S, Kondratyuk TP, Petronio MS, Regasini LO, Silva DH, et al. Suppression of TNF-α induced NFκB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. Nat Prod Res 2010; 24:1758-1765.

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