سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ahmed, Ayesha, Mansour Alkhawajah, Abdulaziz M, Al-Tamimi, Dalal M, Shwarby, Muhammad A, Isab, Anvarhusein A, Badar, Ahmed. (1397). Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound. , 21(10), 1064-1072. doi: 10.22038/ijbms.2018.28622.6935
Ayesha Ahmed; Abdulaziz M Mansour Alkhawajah; Dalal M Al-Tamimi; Muhammad A Shwarby; Anvarhusein A Isab; Ahmed Badar. "Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound". , 21, 10, 1397, 1064-1072. doi: 10.22038/ijbms.2018.28622.6935
Ahmed, Ayesha, Mansour Alkhawajah, Abdulaziz M, Al-Tamimi, Dalal M, Shwarby, Muhammad A, Isab, Anvarhusein A, Badar, Ahmed. (1397). 'Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound', , 21(10), pp. 1064-1072. doi: 10.22038/ijbms.2018.28622.6935
Ahmed, Ayesha, Mansour Alkhawajah, Abdulaziz M, Al-Tamimi, Dalal M, Shwarby, Muhammad A, Isab, Anvarhusein A, Badar, Ahmed. Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound. , 1397; 21(10): 1064-1072. doi: 10.22038/ijbms.2018.28622.6935

Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound

Iranian Journal of Basic Medical Sciences
مقاله 12، دوره 21، شماره 10، دی 2018، صفحه 1064-1072    اصل مقاله (715.37 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.28622.6935
نویسندگان
Ayesha Ahmed* 1؛ Abdulaziz M Mansour Alkhawajah2؛ Dalal M Al-Tamimi1؛ Muhammad A Shwarby1؛ Anvarhusein A Isab3؛ Ahmed Badar4
1Department of Pathology, College of Medicine and King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
2Department of Pharmacology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
3Department of Chemistry, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia
4Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
چکیده
Objective(s): Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and decreased cytotoxicity. In this study, histological toxicity profile of a newly formulated anti-cancerous gold (III) compound [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) was investigated by evaluation of kidney and liver tissues of treated rats.
Materials and Methods: This is a quasi-experimental study. In acute toxicity component of the study, (n = 16) male rats weighing between 200–250 g were administered single, variable concentration of the gold (III) compound, [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) to determine LD50 (dose that is lethal to 50% of rats). An IP injection of 2.3 mg/kg (equivalent to 1/10 of LD50) was injected for 14 consecutive days to (n=10) male rats in the sub-acute component of the study. Autopsy preservation of liver and kidney tissue in buffered formalin, sample processing, histopathological evaluation, and comparison with unremarkable controls (n=5) was conducted sequentially.
Results: A dose of 2.3 mg/kg did not produce any tubular necrosis in kidney specimens. Mild interstitial inflammation with prominence of plasma cells was the main histological alteration. Plasmacytic pyelitis was also seen. Varying extents of cytoplasmic vacuolization and mild focal lobular and portal inflammation were predominant hepatic microscopic findings.
Conclusion: [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) produced no histological damage in renal and hepatic tissues of rats. This very limited sample animal-based study points to the relative safety of this new gold compound. However, there is a need to compare this compound with established drugs in a comparative non-animal based study.
کلیدواژه‌ها
Anticancerous؛ Kidney؛ Liver؛ Novel gold III compound؛ Toxicity
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