The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 1، دوره 9، شماره 1، فروردین و اردیبهشت 2019، صفحه 1-9 اصل مقاله (565.32 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2018.11294 | ||
| نویسندگان | ||
| Mostafa Dastani1؛ leila Bigdelu2؛ mahsa hoseinzadeh3؛ Hamid Reza Rahimi4، 5؛ Asieh Karimani3؛ Amir Houshang Mohammadpour6، 7؛ Masoumeh Salari* 8 | ||
| 1Department of cardiology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 6Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 7Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 8Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina. Materials and Methods: Forty patients with unstable angina who met the trial inclusion and exclusion criteria, participated in this double-blind randomized clinical trial. The patients were randomized into two groups: curcumin (80 mg/day for 5days) and placebo (80 mg/day for 5days). Cardiac function was evaluated by two-dimensional echocardiography devices at baseline (immediately after hospitalization) and 5 days after the onset of the trial. Atrial and ventricular arrhythmias were recorded by Holter monitors in cardiology ward, Ghaem academic hospital, Mashhad, Iran. Progression to heart failure, myocardial infarction, and pulmonary and cardiopulmonary resuscitation events as well as mortality were recorded daily throughout the study. Results: There were no significant differences between the two groups in atrial and ventricular arrhythmias (p=0.2), and other echocardiographic parameters (Ejection fraction, E, A, E/A ratio, Em, and pulmonary artery pressure) at baseline and five days after the start of the trial. Conclusion: Nanocurcumin administered at the dose of 80 mg/day for five days had no effect in the incidence of cardiovascular complications in patients with unstable angina. | ||
| کلیدواژهها | ||
| Angina؛ Unstable؛ Arrhythmias؛ Cardiac؛ Curcumin؛ heart failure؛ Acute coronary syndrome | ||
| مراجع | ||
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