سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Havakhah, Shahrzad, Sankian, Mojtaba, Kazemzadeh, Gholam Hosein, sadri, kayvan, Bidkhori, Hamid Reza, Naderi-Meshkin, Hojjat, Ebrahimzadeh Bideskan, Alireza, Niazmand, Saeed, Bahrami, Ahmad Reza, khajavirad, Abolfazl. (1397). In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury. , 21(8), 824-831. doi: 10.22038/ijbms.2018.26829.6566
Shahrzad Havakhah; Mojtaba Sankian; Gholam Hosein Kazemzadeh; kayvan sadri; Hamid Reza Bidkhori; Hojjat Naderi-Meshkin; Alireza Ebrahimzadeh Bideskan; Saeed Niazmand; Ahmad Reza Bahrami; Abolfazl khajavirad. "In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury". , 21, 8, 1397, 824-831. doi: 10.22038/ijbms.2018.26829.6566
Havakhah, Shahrzad, Sankian, Mojtaba, Kazemzadeh, Gholam Hosein, sadri, kayvan, Bidkhori, Hamid Reza, Naderi-Meshkin, Hojjat, Ebrahimzadeh Bideskan, Alireza, Niazmand, Saeed, Bahrami, Ahmad Reza, khajavirad, Abolfazl. (1397). 'In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury', , 21(8), pp. 824-831. doi: 10.22038/ijbms.2018.26829.6566
Havakhah, Shahrzad, Sankian, Mojtaba, Kazemzadeh, Gholam Hosein, sadri, kayvan, Bidkhori, Hamid Reza, Naderi-Meshkin, Hojjat, Ebrahimzadeh Bideskan, Alireza, Niazmand, Saeed, Bahrami, Ahmad Reza, khajavirad, Abolfazl. In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury. , 1397; 21(8): 824-831. doi: 10.22038/ijbms.2018.26829.6566

In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury

Iranian Journal of Basic Medical Sciences
مقاله 9، دوره 21، شماره 8، آبان 2018، صفحه 824-831    اصل مقاله (1.38 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.26829.6566
نویسندگان
Shahrzad Havakhah1؛ Mojtaba Sankian2؛ Gholam Hosein Kazemzadeh3؛ kayvan sadri4؛ Hamid Reza Bidkhori5؛ Hojjat Naderi-Meshkin5؛ Alireza Ebrahimzadeh Bideskan6؛ Saeed Niazmand1، 7؛ Ahmad Reza Bahrami5، 8؛ Abolfazl khajavirad* 1، 7
1Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Vascular Surgery, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran
6Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
7Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده
Objective(s): Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induced AKI Wistar rats and evaluating their significance in AKI treatment.
Material and Methods: Animals underwent surgical procedure and AKI was induced by 40 min bilateral renal pedicle clamping. Immediately after reperfusion, 2×106 rat bone marrow derived MSCs were injected via intra-parenchymal or intra-aortic route.
Results: Animals subjected to AKI after days 1 and 3 showed significant increase in the serum creatinine and blood urea nitrogen (BUN) concentration along with a declined glomerular filtration rate (GFR) when compared with non-ischemic animals. On the other hand, treated animals showed a significant enhanced regeneration as compared to ischemic animals in both administration route groups.
Conclusion: According to the results concluded from the renoprotective effects of MSC in IRI/AKI, MSCs could be considered as promising therapeutic approach for AKI in clinical applications.
کلیدواژه‌ها
Acute kidney injury؛ Acute renal failure؛ Bone marrow-derived mesenchymal stem cell؛ Cell transplantation؛ Ischemic kidney injury؛ Rat
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