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Ranjbar, Hoda, Aghaei, Iraj, Moosazadeh, Mahmood, Shabani, Mohammad. (1397). Angiotensin II type 1 receptor blocker losartan attenuates locomotor, anxiety-like behavior and passive avoidance learning deficits in a sub-chronic stress model. , 21(8), 856-862. doi: 10.22038/ijbms.2018.27113.6632
Hoda Ranjbar; Iraj Aghaei; Mahmood Moosazadeh; Mohammad Shabani. "Angiotensin II type 1 receptor blocker losartan attenuates locomotor, anxiety-like behavior and passive avoidance learning deficits in a sub-chronic stress model". , 21, 8, 1397, 856-862. doi: 10.22038/ijbms.2018.27113.6632
Ranjbar, Hoda, Aghaei, Iraj, Moosazadeh, Mahmood, Shabani, Mohammad. (1397). 'Angiotensin II type 1 receptor blocker losartan attenuates locomotor, anxiety-like behavior and passive avoidance learning deficits in a sub-chronic stress model', , 21(8), pp. 856-862. doi: 10.22038/ijbms.2018.27113.6632
Ranjbar, Hoda, Aghaei, Iraj, Moosazadeh, Mahmood, Shabani, Mohammad. Angiotensin II type 1 receptor blocker losartan attenuates locomotor, anxiety-like behavior and passive avoidance learning deficits in a sub-chronic stress model. , 1397; 21(8): 856-862. doi: 10.22038/ijbms.2018.27113.6632

Angiotensin II type 1 receptor blocker losartan attenuates locomotor, anxiety-like behavior and passive avoidance learning deficits in a sub-chronic stress model

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 21، شماره 8، آبان 2018، صفحه 856-862    اصل مقاله (618.58 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.27113.6632
نویسندگان
Hoda Ranjbar1؛ Iraj Aghaei2؛ Mahmood Moosazadeh3؛ Mohammad Shabani* 1
1ntracellular Recording Lab, Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
2Social Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran
3Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Objective(s): Stress alters sensory and cognitive function in humans and animals. Angiotensin (AT) receptors have demonstrated well-established interactions in sets of physiological phenomena. AT1 receptors can play a part in stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis; besides angiotensinergic neurotransmission plays a pivotal role in stress-evoked physiological responses. AT1 receptors are also involved in nociception and memory. The objective of the current study was to evaluate the effects of losartan as an AT1R antagonist in locomotor activity, nociception and memory impairments induced by sub-chronic swim stress.
Materials and Methods: A two-session forced swimming stress protocol was administered to the rats. Pretreatment with losartan (10 mg/kg, IP) or saline was made before each swimming session. Locomotor activity, anxiety-like behavior, nociception, and passive avoidance learning were evaluated 24 hr after last swim stress session.
Results: Swim stress induced increased anxiety-like behavior in the open field test, which pretreatment with losartan did counterbalance. Increased thermal threshold was observed in the nociceptive measurement after swim stress. Pretreatment with losartan attenuated the increased threshold and also inhibited a decreased step-through latency that was observed in the memory paradigm after swim stress.
Conclusion: The results of this study indicate that sub-chronic swim stress impairs passive avoidance learning, anxiety-like behaviors, and nociception; and AT1 receptor seems to have a modulatory role in these alterations. However, further studies are suggested to examine the protective effect of AT1R inhibitors on stress-induced impairments in sensory and cognitive function.
کلیدواژه‌ها
Acetylsalicylic acid؛ Antioxidants؛ Epididymis؛ Melatonin؛ Sperm؛ Testosterone
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