Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 4، دوره 2، شماره 4، آذر 2012، صفحه 196-205 اصل مقاله (244.78 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2012.109 | ||
| نویسندگان | ||
| Esmaeal Tamaddonfard* ؛ Amir Erfanparast؛ Nasrin Hamzeh-Gooshchi؛ Shahnaz Yousofizadeh | ||
| Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 57153-1177, I.R. Iran | ||
| چکیده | ||
| Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p<0.05) reduced both frequency and amplitude of spike waves. Co-administrations of curcumin (50 mg/kg, i.p.) with diazepam (5 µg, i.c.v.) enhanced the antiepileptic effect of diazepam (5 µg, i.c.v.). Conclusion: The results suggested that both curcumin and diazepam suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between curcumin and diazepam in reducing penicillin-induced seizures. | ||
| کلیدواژهها | ||
| Curcumin؛ Diazepam؛ Penicillin-Induced Seizures؛ Rats | ||
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