سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Araki, Raita, Nishimura, Ryosei, Inaki, Anri, Wakabayashi, Hiroshi, Imai, Yasuhito, Kuribayashi, Yoshikazu, Yoshimura, Kenichi, Murayama, Toshinori, Kinuya, Seigo. (1397). Feasibility of high-dose iodine-131-metaiodobenzylguanidine therapy for high-risk neuroblastoma preceding myeloablative chemotherapy and hematopoietic stem cell transplantation: a study protocol. , 6(2), 161-166. doi: 10.22038/aojnmb.2018.29845.1203
Raita Araki; Ryosei Nishimura; Anri Inaki; Hiroshi Wakabayashi; Yasuhito Imai; Yoshikazu Kuribayashi; Kenichi Yoshimura; Toshinori Murayama; Seigo Kinuya. "Feasibility of high-dose iodine-131-metaiodobenzylguanidine therapy for high-risk neuroblastoma preceding myeloablative chemotherapy and hematopoietic stem cell transplantation: a study protocol". , 6, 2, 1397, 161-166. doi: 10.22038/aojnmb.2018.29845.1203
Araki, Raita, Nishimura, Ryosei, Inaki, Anri, Wakabayashi, Hiroshi, Imai, Yasuhito, Kuribayashi, Yoshikazu, Yoshimura, Kenichi, Murayama, Toshinori, Kinuya, Seigo. (1397). 'Feasibility of high-dose iodine-131-metaiodobenzylguanidine therapy for high-risk neuroblastoma preceding myeloablative chemotherapy and hematopoietic stem cell transplantation: a study protocol', , 6(2), pp. 161-166. doi: 10.22038/aojnmb.2018.29845.1203
Araki, Raita, Nishimura, Ryosei, Inaki, Anri, Wakabayashi, Hiroshi, Imai, Yasuhito, Kuribayashi, Yoshikazu, Yoshimura, Kenichi, Murayama, Toshinori, Kinuya, Seigo. Feasibility of high-dose iodine-131-metaiodobenzylguanidine therapy for high-risk neuroblastoma preceding myeloablative chemotherapy and hematopoietic stem cell transplantation: a study protocol. , 1397; 6(2): 161-166. doi: 10.22038/aojnmb.2018.29845.1203

Feasibility of high-dose iodine-131-metaiodobenzylguanidine therapy for high-risk neuroblastoma preceding myeloablative chemotherapy and hematopoietic stem cell transplantation: a study protocol

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 11، دوره 6، شماره 2، مهر 2018، صفحه 161-166    اصل مقاله (533.6 K)
نوع مقاله: Others
شناسه دیجیتال (DOI): 10.22038/aojnmb.2018.29845.1203
نویسندگان
Raita Araki* 1؛ Ryosei Nishimura1؛ Anri Inaki2؛ Hiroshi Wakabayashi2؛ Yasuhito Imai3؛ Yoshikazu Kuribayashi3؛ Kenichi Yoshimura3؛ Toshinori Murayama3؛ Seigo Kinuya2
1Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan
2Department of Nuclear Medicine, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan
3Innovative Clinical Research Center, Kanazawa University, Japan
چکیده
Objective(s): High-risk neuroblastoma is a childhood cancer with poor
prognosis despite modern multimodality therapy. Internal radiotherapy using
131I-metaiodobenzylguanidine (MIBG) is effective for treating the disease even if it is
resistant to chemotherapy. The aim of this study is to evaluate the safety and efficacy
of 131I-MIBG radiotherapy combined with myeloablative high-dose chemotherapy
and hematopoietic stem cell transplantation.
Methods: Patients with high-risk neuroblastoma will be enrolled in this study. A total
of 8 patients will be registered. Patients will receive 666 MBq/kg of 131I-MIBG and
after safety evaluation will undergo high-dose chemotherapy and hematopoietic stem
cell transplantation. Autologous and allogeneic stem cell sources will be accepted.
After engraftment or 28 days after hematopoietic stem cell transplantation, the safety
and response will be evaluated.
Conclusion: This is the first prospective study of 131I-MIBG with high-dose
chemotherapy and hematopoietic stem cell transplantation in Japan. The results will
be the basis of a future nationwide clinical trial.
کلیدواژه‌ها
131I-MIBG؛ Neuroblastoma؛ Hematopoietic stem cell transplantation؛ Prospective study protocol
مراجع
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