Validation of Optimum ROI Size for 123I-FP-CIT SPECT Imaging Using a 3D Mathematical Cylinder Phantom | ||
| Asia Oceania Journal of Nuclear Medicine and Biology | ||
| مقاله 8، دوره 6، شماره 2، مهر 2018، صفحه 139-148 اصل مقاله (2.81 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/aojnmb.2018.10638 | ||
| نویسندگان | ||
| Hideo Onishi* 1؛ Takayuki SAKAI2؛ Osamu SHIROMOTO3؛ Hizuru Amijima4 | ||
| 1Program in Health and Welfare Graduate School of Comprehensive Scientific Research Prefectural university of Hiroshima | ||
| 21-1, Sonekitamachi, Kokura-Minami-ku, Kitakyusyu, Fukuoka, 800-0296, Japan | ||
| 3Program in Health and Welfare Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima 1-1, Gakuenmachi, Mihara, Hiroshima, 723-0053, Japan | ||
| 4Department of Nursing，Hyogo University of Health Sciences | ||
| چکیده | ||
| Objective(s): The partial volume effect (PVE) of single-photon emission computed tomography (SPECT) on corpus striatum imaging is caused by the underestimation of specific binding ratio (SBR). A large ROI (region of interest) set using the Southampton method is independent of PVE for SBR. The present study aimed to determine the optimal ROI size with contrast and SBR for striatum images and validate the Southampton method using a three-dimensional mathematical cylinder (3D-MAC) phantom. Methods: We used ROIs sizes of 27, 36, 44, 51, 61, 68, and 76 mm for targets with diameters 40, 20, and 10 mm on reference and processed images reconstructed using the 3D-MAC phantom. Contrast values and SBR were compared with the theoretical values to obtain the optimal ROI size. Results: The contrast values in the ROI with diameters of 51 (target: 40 mm in diameter) and 44 (target: 20 mm in diameter) mm matched the theoretical values. However, this value did not correspond with the 10-mm-diameter target. The SBR matched the theoretical value with an ROI of > 44 mm in the 20-mm-diameter target;but, it was under- and overestimated under any other conditions. Conclusion: These results suggested that an ROI should be 4-2 folds larger than the target size without PVE, and that the Southampton method was remarkably accurate. | ||
| کلیدواژهها | ||
| specific binding ratio؛ partial volume effect؛ Southampton method | ||
| مراجع | ||
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