The role of nanoliposome bilayer composition containing soluble leishmania antigen on maturation and activation of dendritic cells | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 15، دوره 21، شماره 5، مرداد 2018، صفحه 536-545 اصل مقاله (1.51 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2018.25976.6391 | ||
| نویسندگان | ||
| Sara Shokooh Saremi1، 2؛ Maryam Shahryari1، 2؛ Razieh Ghoorchian1؛ Hamed Eshaghian1؛ Seyed Amir Jalali3؛ Amin Nikpoor4؛ Mahmoud Reza Jaafari1، 2، 5؛ Ali Badiee* 1، 2 | ||
| 1Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 4Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): Dendritic cells (DCs) play a critical role in activation of T cell responses. Induction of type1 T helper (Th1) immune response is essential to generate protective immunity against cutaneous leishmaniasis. The intrinsic tendency of liposomes to have interaction with antigen-presenting cells is the main rationale to utilize liposomes as antigen carriers. In the present study, the effect of lipid phase transition temperature on DCs maturation and liposome uptake by murine bone marrow derived dendritic cells and human monocyte derived dendritic cells was investigated. Materials and Methods: Two cationic liposomal formulations consisting of DOTAP and DSPC/DOTAP were prepared and contained soluble leishmania antigen. Liposomes were incubated with immature or mature DCs derived from bone marrow (BMDCs) of C57BL/6 (which are resistant to cutaneous leishmaniasis), BALB/c mice (susceptible to cutaneous leishmaniasis) or DCs derived from human monocytes (MoDCs). The expression of DCs co-stimulatory markers and liposomal uptake were evaluated by flow cytometry method. Results: DCs which were encountered to liposomes consisting of DSPC showed significantly more expression of co-stimulatory molecules in cells from both human and C57BL/6 mice but not in cells from BALB/c mice. Conclusion: It is concluded that cationic liposomes consisting of DSPC are an effective adjuvant for antigen delivery in case of MoDCs and BMDCs from C57BL/6 mice. Moreover, DCs from different origins act differently in uptake of liposomes. | ||
| کلیدواژهها | ||
| Cationic liposomes؛ Dendritic cells؛ Immune response؛ Leishmaniasis؛ Phase transition temperature؛ Th1 | ||
| مراجع | ||
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