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Habibian, Reza, Delirezh, Nowruz, Farshid, Amir Abbas. (1397). The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice. , 21(5), 483-488. doi: 10.22038/ijbms.2018.26898.6575
Reza Habibian; Nowruz Delirezh; Amir Abbas Farshid. "The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice". , 21, 5, 1397, 483-488. doi: 10.22038/ijbms.2018.26898.6575
Habibian, Reza, Delirezh, Nowruz, Farshid, Amir Abbas. (1397). 'The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice', , 21(5), pp. 483-488. doi: 10.22038/ijbms.2018.26898.6575
Habibian, Reza, Delirezh, Nowruz, Farshid, Amir Abbas. The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice. , 1397; 21(5): 483-488. doi: 10.22038/ijbms.2018.26898.6575

The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice

Iranian Journal of Basic Medical Sciences
مقاله 7، دوره 21، شماره 5، مرداد 2018، صفحه 483-488    اصل مقاله (759.33 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.26898.6575
نویسندگان
Reza Habibian1؛ Nowruz Delirezh* 1؛ Amir Abbas Farshid2
1Division of Immunology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
2Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Objective(s): Allergic Asthma is an inflammatory disease of the lungs that is characterized by increased infiltration of leukocytes into the airways, limiting the respiratory function. Studies suggest that a defective general regulatory system against inflammation could be a significant factor in allergic asthma. It has been shown that Mesenchymal stem cells (MSCs) have a cellular immunosuppressive therapeutic potential for inflammatory disorders. We investigated whether administration of MSCs during allergen challenge would affect the underlying mechanisms in allergic airways inflammation.
Materials and Methods: Fifty mice were used in five control and experimental groups; the experimental mice sensitized by intraperitoneal injection of OVA and aluminum hydroxide emulsion on days 0, 7, and 14, were then challenged intranasally with OVA or sterile PBS on days 14, 25, 26, and 27. Before allergen challenge on day 14, experimental mice received tail vein injection of MSCs in PBS, whereas control mice received PBS alone. Cytokine and IgE analyses were carried out using lung washes as well as serum samples.
Results: Our, results showed that MSCs significantly reduced total cells and eosinophilia and serum OVA-specific IgE concentration in OVA-sensitized and challenged mice. Also, results showed that MSCs markedly inhibited expressions of Th2 and Th17 cytokines and elevated levels of Treg cytokines.
Conclusion: we found that administration of MSCs could be used as a potential therapeutic approach for allergic asthma.
کلیدواژه‌ها
Allergic asthma؛ Mesenchymal stem cells Mice؛ Th17؛ Th2؛ Treg
مراجع
1. Bochner BS, Rothenberg ME, Boyce JA, Finkelman F. Advances in mechanisms of allergy and clinical immunology in 2012. J Allergy and Clin Immunol 2013; 131:661-667.
2. Braman SS. The global burden of asthma. Chest 2006; 130:4S-12S.
3. Choi MS, Park S, Choi T, Lee G, Haam KK, Hong MC et al. Bee venom ameliorates ovalbumin induced allergic asthma via modulating CD4+CD25+ regulatory T cells in mice. Cytokine. 2013; 61(1):256-265.
4. Nakagome K, Nagata M. Pathogenesis of airway inflammation in bronchial asthma. Auris Nasus Larynx 2011; 38:555-563.
5. Braga M, Quecchia C, Cavallucci E, Di Giampaolo L, Schiavone C, Petrarca C et al. T regulatory cells in allergy. Int J Immunopathol Pharmacol 2011; 24:55S-64S.
6. Rasmusson I. Immune modulation by mesenchymal stem cells. Exp Cell Res 2006; 312:2169-2179.
7. Larche M. Regulatory T cells in allergy and asthma. Chest 2007; 132:1007-1014.
8. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8:726-736.
9. Collins E, Gilkeson G. Hematopoetic and mesenchymal stem cell transplantation in the treatment of refractory systemic lupus erythematosus — Where are we now? Clin Immunol 2013;148:328-334.
10. Liang J, Gu F, Wang H, Hua B, Hou Y, Shi S et al. Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. Nat Rev Rheumatol 2010; 6:486-489.
11. El-Jawhari JJ, El-Sherbiny YM, Jones EA, McGonagle D. Mesenchymal stem cells, autoimmunity and rheumatoid arthritis. QJM 2014; 107:505-514.
12. Gonzalez-Rey E, Gonzalez MA, Varela N, O’Valle F, Hernandez-Cortes P, Rico L et al. Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis 2010; 69:241-248.
13. Martínez-Montiel MdP, Gómez-Gómez GJ, Flores AI. Therapy with stem cells in inflammatory bowel disease. World J Gastroenterol (WJG) 2014;20:1211-1227.
14. Van Deen WK, Oikonomopoulos A, Hommes DW. Stem cell therapy in inflammatory bowel disease: which, when and how? Curr Opin Gastroenterol 2013; 29:384-390.
15. Amorin B, Alegretti A, Valim V, Pezzi A, Laureano A, da Silva M et al. Mesenchymal stem cell therapy and acute graft-versus-host disease: a review. Human Cell 2014; 27:137-150.
16. Ringden O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lonnies H et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplant 2006;81:1390-1397.
17. Toonkel RL, Hare JM, Matthay MA, Glassberg MK. Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Am J Respir Crit Care Med 2013; 188:133-140.
18. Sun YQ, Deng MX, He J, Zeng QX, Wen W, Wong DS et al. Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. Stem Cell 2012; 30:2692-2699.
19. Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. Stem cells and regenerative medicine: accomplishments to date and future promise. Ther Deliv 2010; 1:693-705.
20. Kianmehr M, Ghorani V, Boskabady MH. Animal model of asthma, various methods and measured parameters: a methodological review. Iran J Allergy Asthma Immunol 2016; 15:445-465.
21. Nembrini C, Marsland BJ, Kopf M. IL-17-producing T cells in lung immunity and inflammation. J Allergy Clin Immunol 2009; 123:986-994.
22. Lee S-H, Jang A-S, Kwon J-H, Park S-K, Won J-H, Park C-S. Mesenchymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murine asthma model. Allergy, Asthma & Immunol Res 2011; 3:205-211.
23. Ghorbani A, Feizpour A, Hashemzahi M, Gholami L, Hosseini M,  Soukhtanloo M, et al. The effect of adipose derived stromal cells on oxidative stress level, lung emphysema and white blood cells of guinea pigs model of chronic obstructive pulmonary disease. DARU J Pharmaceutical Sci 2014; 22:26-31.
24. Feizpour A, Boskabady MH, Ghorbani A. Adipose-derived stromal cell therapy affects lung inflammation and tracheal responsiveness in guinea pig model of COPD. PLoS ONE 2014; 9:10-16.
25. Miettinen JA, Salonen RJ, Ylitalo K, Niemela M, Kervinen K, Saily M et al. The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction. J Transl Med 2012; 10:1479-1487.
26. Palomares O, Yaman G, Azkur AK, Akkoc T, Akdis M, Akdis CA. Role of Treg in immune regulation of allergic diseases. Eur J Immunol 2010; 40:1232-1240.
27. Mohammadian M, Boskabady MH, Ragerdi Kashani I, Pirzad Jahromi G, Omidi A, Kavian Nejad A, et al. Effect of bone marrow derived mesenchymal stem cells on lung pathology and inflammation in ovalbumin‐induced asthma in mouse. Iran J Basic Med Sci 2016; 19:55-61.
28. Mohammadian M, Sadeghipour HR, Ragerdi Kashan I, Pirzad Jahromi G, Omidi A, Kavian Nejad A. Evaluation of simvastatin and bone marrow-derived mesenchymal stem cell combination therapy on airway remodeling in a mouse asthma model. Lung 2016; 194:777-785.
29. Ci X, Chu X, Wei M, Yang X, Cai Q. Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. PLoS ONE 2012; 7:4-9.
30. Ting Xu, Ling-Ling Xian, Yufeng Zhou, Beverly Plunkett, Xu Cao, Mei Wan et al. TGF-beta1 mobilizes mesenchymal stem cells in allergic asthma. J Allergy and Clin Immunol 2014; 133:53-60.
31. Corren J. Anti-interleukin-5 antibody therapy in asthma and allergies. Curr Opin Allergy Clin Immunol 2011; 11:565-570.
32. Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy 2009; 39:1314-1323.
33. Oboki K, Ohno T, Saito H, Nakae S. Th17 and allergy. Allergol Int 2008; 57:121-134.
34. Alcorn JF, Crowe CR, Kolls JK. TH17 cells in asthma and COPD. Ann Rev Physiol 2010; 72:495-516.
35. Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P et al. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 2010; 138:1140-1147.
36. Shalaby KH, Martin JG. Overview of asthma; the place of the T cell. Curr Opin Pharmacol 2010; 10:218-225.
37. Shi YH, Shi GC, Wan HY, Jiang LH, Ai XY, Zhu HX et al. Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma. Chin Med J 2011; 124:1951-1956.
38.Hou X, Wan H, Ai X, Shi Y, Ni Y, Tang W et al. Histone deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma. Clin Respir J 2014; 13:12227-12235.

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