سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Gholampour, Firouzeh, Khangah, Leila, Vatanparast, Jafar, Karbalaei-Heidari, Hamid Reza, Owji, Seyed Molammad, Bahaoddini, Aminollah. (1397). The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat. , 21(6), 600-606. doi: 10.22038/ijbms.2018.25810.6354
Firouzeh Gholampour; Leila Khangah; Jafar Vatanparast; Hamid Reza Karbalaei-Heidari; Seyed Molammad Owji; Aminollah Bahaoddini. "The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat". , 21, 6, 1397, 600-606. doi: 10.22038/ijbms.2018.25810.6354
Gholampour, Firouzeh, Khangah, Leila, Vatanparast, Jafar, Karbalaei-Heidari, Hamid Reza, Owji, Seyed Molammad, Bahaoddini, Aminollah. (1397). 'The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat', , 21(6), pp. 600-606. doi: 10.22038/ijbms.2018.25810.6354
Gholampour, Firouzeh, Khangah, Leila, Vatanparast, Jafar, Karbalaei-Heidari, Hamid Reza, Owji, Seyed Molammad, Bahaoddini, Aminollah. The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat. , 1397; 21(6): 600-606. doi: 10.22038/ijbms.2018.25810.6354

The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat

Iranian Journal of Basic Medical Sciences
مقاله 8، دوره 21، شماره 6، شهریور 2018، صفحه 600-606    اصل مقاله (772.4 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2018.25810.6354
نویسندگان
Firouzeh Gholampour* 1؛ Leila Khangah1؛ Jafar Vatanparast1؛ Hamid Reza Karbalaei-Heidari2؛ Seyed Molammad Owji3؛ Aminollah Bahaoddini1
1Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
2Department of Biology, College of Science, Shiraz University, Shiraz, Iran
3Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Objective(s): We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats.
Materials and Methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles of 2 min occlusions of the left femoral artery and 3 min reperfusion at the beginning of renal ischemia. The animals were given normal saline (vehicle), NG-nitro-L-arginine methyl ester (L-NAME) or L-arginine. Following the reperfusion period, renal functional- and oxidative stress- parameters, as well as histopathological changes were assessed.
Results: In comparison with the sham group, I/R resulted in renal dysfunction, as indicated by significantly lower creatinine clearance and higher fractional excretion of sodium. This went along with decreased glutathione peroxidase (GPX) and catalase (CAT) activity in the I/R group, increased malondialdehyde (MDA) contents and histological damages. In comparison with the I/R group, the rIPerC group displayed improved renal function, increased activity of GPX and CAT enzymes, and decreased MDA level. However, these effects were abrogated by L-NAME injection and augmented by L-arginine treatment.
Conclusion: According to the results, the functional and structural consequences of rIPerC against I/R-induced kidney dysfunction, which is associated with reduction of lipid peroxidation and intensification of anti-oxidant systems, is partially dependent on NO production.
کلیدواژه‌ها
Kidney؛ Nitric oxide؛ Oxidative stress؛ Remote ischemic per-conditioning؛ Reperfusion injury
مراجع
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